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Gene Review:

thraa - thyroid hormone receptor alpha a

Danio rerio

Synonyms: Nuclear receptor subfamily 1 group A member 1-A, SO:0000704, TR[a]1, TRalpha-1, Thyroid hormone receptor alpha-1, ...

Essner, J.J. et al., Essner, J.J. et al., Jones, I. et al.

Essner, Johnson, Hackett,

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High impact information on thra

Overexpression of thyroid hormone receptor alpha 1 during zebrafish embryogenesis disrupts hindbrain patterning and implicates retinoic acid receptors in the control of hox gene expression [1].
In contrast, embryos treated with retinoic acid alone or embryos injected with thyroid hormone receptor alpha 1 and treated with the thyroid hormone analog TRIAC displayed a similar set of defects, including loss of the midbrain-hindbrain border and severe disruption of the rostral hindbrain [1].
Here we examined the ability of the thyroid hormone receptor alpha 1 to affect early embryonic development by mRNA injection of either repressor or activator forms of the thyroid hormone receptor [1].
Furthermore, injection of either thyroid hormone receptor alpha 1 or v-erbA mRNA repressed a reporter gene that contained a retinoic acid response element, demonstrating the ability of the thyroid hormone receptor alpha 1 to repress retinoic acid signaling during gastrulation [1].
In this report, we describe the cloning of the zebrafish thyroid hormone receptor alpha 1 (TR alpha 1) gene, the cellular counterpart of the viral oncogene v-erbA [2].

Biological context of thra

The zebrafish thyroid hormone receptor alpha 1 is expressed during early embryogenesis and can function in transcriptional repression [2].

Analytical, diagnostic and therapeutic context of thra

Molecular cloning and expression of thyroid hormone receptor alpha during salmonid development [3].

References

Overexpression of thyroid hormone receptor alpha 1 during zebrafish embryogenesis disrupts hindbrain patterning and implicates retinoic acid receptors in the control of hox gene expression. Essner, J.J., Johnson, R.G., Hackett, P.B. Differentiation (1999) [Pubmed]
The zebrafish thyroid hormone receptor alpha 1 is expressed during early embryogenesis and can function in transcriptional repression. Essner, J.J., Breuer, J.J., Essner, R.D., Fahrenkrug, S.C., Hackett, P.B. Differentiation (1997) [Pubmed]
Molecular cloning and expression of thyroid hormone receptor alpha during salmonid development. Jones, I., Rogers, S.A., Kille, P., Sweeney, G.E. Gen. Comp. Endocrinol. (2002) [Pubmed]

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thrab	Danio rerio
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THRA	Homo sapiens
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