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Gene Review

Tbh  -  Tyramine beta hydroxylase

Drosophila melanogaster

Synonyms: CG1543, DBH, Dbh, Dmel\CG1543, T beta h, ...
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Disease relevance of Tbh

  • Fertility of the mutant females is also restored when TBH is expressed, via the GAL4-UAS system, in cells of the CNS abdominal ganglion that express TBH and produce octopamine [1].

High impact information on Tbh

  • T beta h-null flies are octopamine-less but survive to adulthood [2].
  • The deduced amino acid sequence of the encoded protein exhibits 39% identity to the evolutionarily related mammalian dopamine beta-hydroxylase enzyme [2].
  • These data demonstrate that the endogenous signal peptide is not required for the formation of the membranous dopamine beta-hydroxylase and further that the enzyme can be bound to membranes via a mechanism other than uncleaved signal sequence [3].
  • Finally, I demonstrate that these TBH-expressing cells project to the periphery where they innervate the ovaries and the oviducts of the reproductive system [1].

Analytical, diagnostic and therapeutic context of Tbh


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