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Gene Review

Dbh  -  dopamine beta hydroxylase

Mus musculus

Synonyms: Dopamine beta-hydroxylase, Dopamine beta-monooxygenase
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Disease relevance of Dbh


Psychiatry related information on Dbh


High impact information on Dbh


Chemical compound and disease context of Dbh


Biological context of Dbh


Anatomical context of Dbh


Associations of Dbh with chemical compounds


Regulatory relationships of Dbh


Other interactions of Dbh

  • The in vivo developmental profile of DBH approximated that of TH [34].
  • Additional triple-fluorescence experiments revealed the presence of dopamine-beta-hydroxylase immunoreactivity within 25.4 +/- 3.3% of NPY afferents to GnRH neurons [35].
  • We conclude from this study that Arix and NBPhox exhibit indistinguishable and independent transcriptional regulatory properties on the DBH promoter [19].
  • In the dorsal horn of the spinal cord, no differences were detected between GalOE-DBH and WT mice, both displaying a strong galanin-positive neuropil in the superficial laminae of the dorsal horn, but the transgenic mice showed a more abundant galanin-positive innervation of the ventral horn [30].
  • Levels of TH, DBH, and PNMT mRNA were determined by reverse transcription-polymerase chain reaction (RT-PCR) [36].

Analytical, diagnostic and therapeutic context of Dbh


  1. The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Mercer, E.H., Hoyle, G.W., Kapur, R.P., Brinster, R.L., Palmiter, R.D. Neuron (1991) [Pubmed]
  2. Immunohistochemical and histochemical evidence for the presence of noradrenaline, serotonin and gamma-aminobutyric acid in chief cells of the mouse carotid body. Oomori, Y., Nakaya, K., Tanaka, H., Iuchi, H., Ishikawa, K., Satoh, Y., Ono, K. Cell Tissue Res. (1994) [Pubmed]
  3. Concomitant elevation of tyrosine hydroxylase and dopamine beta-hydroxylase by cyclic AMP in cultured mouse neuroblastoma cells. Waymire, J.C., Gilmer-Waymire, K., Boehme, R.E. J. Neurochem. (1978) [Pubmed]
  4. Norepinephrine is required for leptin effects on gene expression in brown and white adipose tissue. Commins, S.P., Marsh, D.J., Thomas, S.A., Watson, P.M., Padgett, M.A., Palmiter, R., Gettys, T.W. Endocrinology (1999) [Pubmed]
  5. Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling. Zhang, H., Cotecchia, S., Thomas, S.A., Tanoue, A., Tsujimoto, G., Faber, J.E. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  6. Impaired maternal behavior in mice lacking norepinephrine and epinephrine. Thomas, S.A., Palmiter, R.D. Cell (1997) [Pubmed]
  7. Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals. Weinshenker, D., Miller, N.S., Blizinsky, K., Laughlin, M.L., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Genetic reduction of noradrenergic function alters social memory and reduces aggression in mice. Marino, M.D., Bourdélat-Parks, B.N., Cameron Liles, L., Weinshenker, D. Behav. Brain Res. (2005) [Pubmed]
  9. Noradrenaline is necessary for the hedonic properties of addictive drugs. Jasmin, L., Narasaiah, M., Tien, D. Vascul. Pharmacol. (2006) [Pubmed]
  10. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Thomas, S.A., Palmiter, R.D. Nature (1997) [Pubmed]
  11. Noradrenaline is essential for mouse fetal development. Thomas, S.A., Matsumoto, A.M., Palmiter, R.D. Nature (1995) [Pubmed]
  12. Stimulation of the pituitary-adrenocortical axis by nerve growth factor. Otten, U., Baumann, J.B., Girard, J. Nature (1979) [Pubmed]
  13. Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. Laghmani, K., Preisig, P.A., Moe, O.W., Yanagisawa, M., Alpern, R.J. J. Clin. Invest. (2001) [Pubmed]
  14. Norepinephrine and epinephrine-deficient mice are hyperinsulinemic and have lower blood glucose. Ste Marie, L., Palmiter, R.D. Endocrinology (2003) [Pubmed]
  15. Dopamine beta-Hydroxylase Knockout Mice have Alterations in Dopamine Signaling and are Hypersensitive to Cocaine. Schank, J.R., Ventura, R., Puglisi-Allegra, S., Alcaro, A., Cole, C.D., Liles, L.C., Seeman, P., Weinshenker, D. Neuropsychopharmacology (2006) [Pubmed]
  16. Norepinephrine is required for the anticonvulsant effect of the ketogenic diet. Szot, P., Weinshenker, D., Rho, J.M., Storey, T.W., Schwartzkroin, P.A. Brain Res. Dev. Brain Res. (2001) [Pubmed]
  17. Locomotor stimulation by L-dopa: relative importance of noradrenaline receptor activation. Andén, N.E., Strömbom, U., Svensson, T.H. Psychopharmacology (Berl.) (1977) [Pubmed]
  18. Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Pilz, A., Moseley, H., Peters, J., Abbott, C. Genomics (1992) [Pubmed]
  19. Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription. Adachi, M., Browne, D., Lewis, E.J. DNA Cell Biol. (2000) [Pubmed]
  20. Analysis of brain adrenergic receptors in dopamine-beta-hydroxylase knockout mice. Sanders, J.D., Szot, P., Weinshenker, D., Happe, H.K., Bylund, D.B., Murrin, L.C. Brain Res. (2006) [Pubmed]
  21. Norepinephrine facilitates the development of the murine sweat response but is not essential. Tafari, A.T., Thomas, S.A., Palmiter, R.D. J. Neurosci. (1997) [Pubmed]
  22. Neurochemical and immunocytochemical studies of catecholamine system in the brindled mouse. Satoh, J., Irino, M., Martin, P.M., Mailman, R.B., Suzuki, K. J. Neuropathol. Exp. Neurol. (1991) [Pubmed]
  23. Effects of systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to mice on tyrosine hydroxylase, L-3,4-dihydroxyphenylalanine decarboxylase, dopamine beta-hydroxylase, and monoamine oxidase activities in the striatum and hypothalamus. Mogi, M., Harada, M., Kojima, K., Kiuchi, K., Nagatsu, T. J. Neurochem. (1988) [Pubmed]
  24. LHRH and catecholamine neuronal systems in the olfactory bulb of the mouse. Rosser, A.E., Hökfelt, T., Goldstein, M. J. Comp. Neurol. (1986) [Pubmed]
  25. Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers. Darrow, K.N., Simons, E.J., Dodds, L., Liberman, M.C. J. Comp. Neurol. (2006) [Pubmed]
  26. The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Jasmin, L., Tien, D., Weinshenker, D., Palmiter, R.D., Green, P.G., Janni, G., Ohara, P.T. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Catecholaminergic properties of cholinergic neurons and synapses in adult rat ciliary ganglion. Landis, S.C., Jackson, P.C., Fredieu, J.R., Thibault, J. J. Neurosci. (1987) [Pubmed]
  28. Peptides that regulate food intake: norepinephrine is not required for reduction of feeding induced by cholecystokinin. Cannon, C.M., Palmiter, R.D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  29. Transient tyrosine hydroxylase-immunoreactive neurons in the region of the anterior olfactory nucleus of pre- and postnatal mice do not contain dopamine. Nagatsu, I., Komori, K., Takeuchi, T., Sakai, M., Yamada, K., Karasawa, N. Brain Res. (1990) [Pubmed]
  30. Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processing. Brumovsky, P., Hygge-Blakeman, K., Villar, M.J., Watanabe, M., Wiesenfeld-Hallin, Z., Hökfelt, T. J. Chem. Neuroanat. (2006) [Pubmed]
  31. Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice. Gestblom, C., Sweetser, D.A., Doggett, B., Kapur, R.P. Am. J. Pathol. (1999) [Pubmed]
  32. Alteration of neurotransmitter phenotype in noradrenergic neurons of transgenic mice. Cadd, G.G., Hoyle, G.W., Quaife, C.J., Marck, B., Matsumoto, A.M., Brinster, R.L., Palmiter, R.D. Mol. Endocrinol. (1992) [Pubmed]
  33. Effects of norlaudanosolinecarboxylic acids on enzymes of catecholamine metabolism. Coscia, C.J., Burke, W.J., Galloway, M.P., Kosloff, A.H., Lasala, J.M., McFarlane, J., Mitchell, J.S., O'Toole, M.M., Roth, B.L. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  34. Development of catecholaminergic phenotypic characters in the mouse locus coeruleus in vivo and in culture. Dreyfus, C.F., Markey, K.A., Goldstein, M., Black, I.B. Dev. Biol. (1983) [Pubmed]
  35. Origin of neuropeptide Y-containing afferents to gonadotropin-releasing hormone neurons in male mice. Turi, G.F., Liposits, Z., Moenter, S.M., Fekete, C., Hrabovszky, E. Endocrinology (2003) [Pubmed]
  36. Catecholamine synthesizing enzymes and their modulation by immobilization stress in knockout mice. Kubovcakova, L., Tybitanclova, K., Sabban, E.L., Majzoub, J., Zorad, S., Vietor, I., Wagner, E.F., Krizanova, O., Kvetnansky, R. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  37. c-Fos deficiency inhibits induction of mRNA for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress. Serova, L.I., Saez, E., Spiegelman, B.M., Sabban, E.L. J. Neurochem. (1998) [Pubmed]
  38. Multiple neuropeptides in nerves supplying mammalian lymph nodes: messenger candidates for sensory and autonomic neuroimmunomodulation? Fink, T., Weihe, E. Neurosci. Lett. (1988) [Pubmed]
  39. Tyrosine hydroxylase and dopamine-beta-hydroxylase immunoreactivities in the cnidarian Renilla koellikeri. Anctil, M., Hurtubise, P., Gillis, M.A. Cell Tissue Res. (2002) [Pubmed]
  40. Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice. Ma, W., Eisenach, J.C. Brain Res. (2003) [Pubmed]
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