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Gene Review:

Trf2 - TATA box binding protein-related factor 2

Drosophila melanogaster

Synonyms: CG11195, CG18009, Dmel\CG18009, TLF, TRF2, ...

Kopytova, D.V. et al., Hochheimer, A. et al., Jin, J.S. et al.

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High impact information on Trf2

TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila [1].
We also identified additional TRF2-responsive target genes involved in DNA replication and cell proliferation [1].
The trf2 gene is strongly expressed in germ line cells of adult flies [2].
High levels of TRF2 are found in nuclei of primary spermatocytes and trophocytes with intense transcription [2].
Both TRF2 forms are detected at the same sites on polytene chromosomes and have the same expression patterns, suggesting that they fulfill similar functions [2].

Biological context of Trf2

Here we report the antibody affinity purification of a Drosophila TRF2-containing complex that contains components of the nucleosome remodelling factor (NURF) chromatin remodelling complex as well as the DNA replication-related element (DRE)-binding factor DREF [1].
Two Isoforms of Drosophila TRF2 Are Involved in Embryonic Development, Premeiotic Chromatin Condensation, and Proper Differentiation of Germ Cells of Both Sexes [2].
Furthermore, double-stranded RNA interference (dsRNAi) experiments were performed to ablate transcription factors such as TBP, TRF1, TRF2 and DREF in Schneider cells [3].

Anatomical context of Trf2

In ovaries, TRF2 is present both in actively transcribing nurse cells and in the transcriptionally inactive oocyte nuclei [2].

References

TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila. Hochheimer, A., Zhou, S., Zheng, S., Holmes, M.C., Tjian, R. Nature (2002) [Pubmed]
Two Isoforms of Drosophila TRF2 Are Involved in Embryonic Development, Premeiotic Chromatin Condensation, and Proper Differentiation of Germ Cells of Both Sexes. Kopytova, D.V., Krasnov, A.N., Kopantceva, M.R., Nabirochkina, E.N., Nikolenko, J.V., Maksimenko, O., Kurshakova, M.M., Lebedeva, L.A., Yerokhin, M.M., Simonova, O.B., Korochkin, L.I., Tora, L., Georgiev, P.G., Georgieva, S.G. Mol. Cell. Biol. (2006) [Pubmed]
A DNA replication-related element downstream from the initiation site of Drosophila selenophosphate synthetase 2 gene is essential for its transcription. Jin, J.S., Baek, S., Lee, H., Oh, M.Y., Koo, Y.E., Shim, M.S., Kwon, S.Y., Jeon, I., Park, S.Y., Baek, K., Yoo, M.A., Hatfield, D.L., Lee, B.J. Nucleic Acids Res. (2004) [Pubmed]

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