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Gene Review

Ptp10D  -  Protein tyrosine phosphatase 10D

Drosophila melanogaster

Synonyms: 10D, CG1817, CT4920, DPTP, DPTP10D, ...
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High impact information on Ptp10D

  • DLAR and DPTP99A are apparently expressed on most or all axons, while DPTP10D is primarily localized to the anterior commissure and its junctions with the longitudinal tracts [1].
  • Transmembrane glycoprotein gp150 is a substrate for receptor tyrosine phosphatase DPTP10D in Drosophila cells [2].
  • Phosphotyrosines on gp150 might function as binding sites for downstream signaling molecules, thereby initiating a signaling cascade that could be modulated in vivo by RPTPs such as DPTP10D [2].
  • DPTP52F, DPTP10D and DPTP69D have partially redundant roles in regulation of guidance decisions made by axons within the ISN and ISNb motor nerves [3].
  • We suggest that DPTP10D may function in vivo to regulate phosphorylation of gp150 and thereby control its interactions with downstream effectors [4].

Biological context of Ptp10D


Anatomical context of Ptp10D

  • RPTP-BK has also significant homology with Drosophila DPTP10D in the phosphatase domain, whose expression is localized exclusively in growth cones of the embryonal brains [8].

Associations of Ptp10D with chemical compounds


Other interactions of Ptp10D

  • DLAR and DPTP4E transcripts are found in the germline during the same developmental stages as DPTP10D transcripts, but their transcripts are not localized to the oocyte [6].


  1. Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo. Tian, S.S., Tsoulfas, P., Zinn, K. Cell (1991) [Pubmed]
  2. Transmembrane glycoprotein gp150 is a substrate for receptor tyrosine phosphatase DPTP10D in Drosophila cells. Fashena, S.J., Zinn, K. Mol. Cell. Biol. (1997) [Pubmed]
  3. Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F. Schindelholz, B., Knirr, M., Warrior, R., Zinn, K. Development (2001) [Pubmed]
  4. An adhesion molecule-like protein that interacts with and is a substrate for a Drosophila receptor-linked protein tyrosine phosphatase. Tian, S.S., Zinn, K. J. Biol. Chem. (1994) [Pubmed]
  5. Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo. Sun, Q., Bahri, S., Schmid, A., Chia, W., Zinn, K. Development (2000) [Pubmed]
  6. Expression of protein tyrosine phosphatase genes during oogenesis in Drosophila melanogaster. Fitzpatrick, K.A., Gorski, S.M., Ursuliak, Z., Price, J.V. Mech. Dev. (1995) [Pubmed]
  7. Identification of a rat protein tyrosine phosphatase gene preferentially expressed in the embryonal brain. Tagawa, M., Shirasawa, T., Fujimura, S., Sakiyama, S. Cell. Mol. Biol. Res. (1994) [Pubmed]
  8. Identification of a receptor-type protein tyrosine phosphatase expressed in postmitotic maturing neurons: its structure and expression in the central nervous system. Tagawa, M., Shirasawa, T., Yahagi, Y., Tomoda, T., Kuroyanagi, H., Fujimura, S., Sakiyama, S., Maruyama, N. Biochem. J. (1997) [Pubmed]
  9. Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Yang, X.H., Seow, K.T., Bahri, S.M., Oon, S.H., Chia, W. Cell (1991) [Pubmed]
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