The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ptp69D  -  Protein tyrosine phosphatase 69D

Drosophila melanogaster

Synonyms: 69D, CG10975, CT30751, DPTP, DPTP69D, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ptp69D


High impact information on Ptp69D


Biological context of Ptp69D


Anatomical context of Ptp69D

  • We propose PTP69D promotes R1-R6 targeting in response to extracellular signals by dephosphorylating substrate(s) in R1-R6 growth cones [3].
  • These targeting errors are difficult to reconcile with models in which PTP69D plays an instructive role in photoreceptor axon targeting, as previously proposed [6].
  • In the optic lobes, DPTP69D is localized to the neuropils of the lamina and medulla, and to an array of parallel thick bundles that may be the transmedullary fibers of the developing lobula complex [9].

Associations of Ptp69D with chemical compounds


Other interactions of Ptp69D

  • DPTP52F, DPTP10D and DPTP69D have partially redundant roles in regulation of guidance decisions made by axons within the ISN and ISNb motor nerves [10].
  • Three RPTPs, known as DLAR, DPTP69D, and DPTP99A, have been genetically characterized thus far [5].
  • These data define three major HRP proteins as neurotactin, fasciclin I, and an R-PTP, DPTP69D [9].
  • In support of this hypothesis, we demonstrate that SHP-2, a vertebrate PTPase similar to Csw and previously implicated in RTK signaling, encodes the functional vertebrate homologue of Csw [11].
  • One of these, corkscrew (csw), encodes an SH2 domain-containing PTPase that appears to be a homolog of mammalian PTP1D [12].


  1. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. Krueger, N.X., Streuli, M., Saito, H. EMBO J. (1990) [Pubmed]
  2. Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Desai, C.J., Gindhart, J.G., Goldstein, L.S., Zinn, K. Cell (1996) [Pubmed]
  3. Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Garrity, P.A., Lee, C.H., Salecker, I., Robertson, H.C., Desai, C.J., Zinn, K., Zipursky, S.L. Neuron (1999) [Pubmed]
  4. A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Streuli, M., Krueger, N.X., Tsai, A.Y., Saito, H. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo. Sun, Q., Bahri, S., Schmid, A., Chia, W., Zinn, K. Development (2000) [Pubmed]
  6. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Newsome, T.P., Asling, B., Dickson, B.J. Development (2000) [Pubmed]
  7. Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Sun, Q., Schindelholz, B., Knirr, M., Schmid, A., Zinn, K. Mol. Cell. Neurosci. (2001) [Pubmed]
  8. Expression of protein tyrosine phosphatase genes during oogenesis in Drosophila melanogaster. Fitzpatrick, K.A., Gorski, S.M., Ursuliak, Z., Price, J.V. Mech. Dev. (1995) [Pubmed]
  9. A Drosophila receptor tyrosine phosphatase expressed in the embryonic CNS and larval optic lobes is a member of the set of proteins bearing the "HRP" carbohydrate epitope. Desai, C.J., Popova, E., Zinn, K. J. Neurosci. (1994) [Pubmed]
  10. Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F. Schindelholz, B., Knirr, M., Warrior, R., Zinn, K. Development (2001) [Pubmed]
  11. The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Perkins, L.A., Johnson, M.R., Melnick, M.B., Perrimon, N. Dev. Biol. (1996) [Pubmed]
  12. Drosophila protein tyrosine phosphatases. Zinn, K. Semin. Cell Biol. (1993) [Pubmed]
WikiGenes - Universities