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Gene Review

PTPRB  -  protein tyrosine phosphatase, receptor...

Homo sapiens

Synonyms: HPTP-BETA, HPTPB, PTPB, Protein-tyrosine phosphatase beta, R-PTP-BETA, ...
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Disease relevance of PTPRB


High impact information on PTPRB


Chemical compound and disease context of PTPRB


Biological context of PTPRB


Anatomical context of PTPRB


Associations of PTPRB with chemical compounds

  • A chromogenic assay based on the Malachite Green method was employed for the detection of inorganic phosphate (Pi) released from phosphopeptides by HPTP beta [16].
  • The cytoplasmic domain of HPTP beta was strongly inhibited by vanadate, molybdate, heparin, poly(Glu, Tyr) (4:1) and zinc ions [16].

Regulatory relationships of PTPRB


Other interactions of PTPRB


Analytical, diagnostic and therapeutic context of PTPRB


  1. Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Foehr, E.D., Lorente, G., Kuo, J., Ram, R., Nikolich, K., Urfer, R. Cancer Res. (2006) [Pubmed]
  2. Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. Yahiro, K., Niidome, T., Kimura, M., Hatakeyama, T., Aoyagi, H., Kurazono, H., Imagawa, K., Wada, A., Moss, J., Hirayama, T. J. Biol. Chem. (1999) [Pubmed]
  3. Implication of a protein-tyrosine-phosphatase in human lung cancer. Gaits, F., Li, R.Y., Ragab, A., Selves, J., Ragab-Thomas, J.M., Chap, H. Cell. Mol. Biol. (Noisy-le-grand) (1994) [Pubmed]
  4. Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling. Peles, E., Schlessinger, J., Grumet, M. Trends Biochem. Sci. (1998) [Pubmed]
  5. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. Krueger, N.X., Streuli, M., Saito, H. EMBO J. (1990) [Pubmed]
  6. Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta. Holland, S.J., Peles, E., Pawson, T., Schlessinger, J. Curr. Opin. Neurobiol. (1998) [Pubmed]
  7. Identification and functions of chondroitin sulfate in the milieu of neural stem cells. Ida, M., Shuo, T., Hirano, K., Tokita, Y., Nakanishi, K., Matsui, F., Aono, S., Fujita, H., Fujiwara, Y., Kaji, T., Oohira, A. J. Biol. Chem. (2006) [Pubmed]
  8. Expression and characterization of wild type, truncated, and mutant forms of the intracellular region of the receptor-like protein tyrosine phosphatase HPTP beta. Wang, Y., Pallen, C.J. J. Biol. Chem. (1992) [Pubmed]
  9. Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas. Ulbricht, U., Brockmann, M.A., Aigner, A., Eckerich, C., Müller, S., Fillbrandt, R., Westphal, M., Lamszus, K. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  10. The gene for receptor-like protein tyrosine phosphatase (PTPRB) is assigned to chromosome 12q15-->q21. Harder, K.W., Anderson, L.L., Duncan, A.M., Jirik, F.R. Cytogenet. Cell Genet. (1992) [Pubmed]
  11. Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin. Pariser, H., Ezquerra, L., Herradon, G., Perez-Pinera, P., Deuel, T.F. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. Ulbricht, U., Eckerich, C., Fillbrandt, R., Westphal, M., Lamszus, K. J. Neurochem. (2006) [Pubmed]
  13. Substrate specificities of catalytic fragments of protein tyrosine phosphatases (HPTP beta, LAR, and CD45) toward phosphotyrosylpeptide substrates and thiophosphotyrosylated peptides as inhibitors. Cho, H., Krishnaraj, R., Itoh, M., Kitas, E., Bannwarth, W., Saito, H., Walsh, C.T. Protein Sci. (1993) [Pubmed]
  14. Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. Adamsky, K., Schilling, J., Garwood, J., Faissner, A., Peles, E. Oncogene (2001) [Pubmed]
  15. Interaction of PTPB with the insulin receptor precursor during its biosynthesis in the endoplasmic reticulum. Issad, T., Boute, N., Boubekeur, S., Lacasa, D. Biochimie (2005) [Pubmed]
  16. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. Harder, K.W., Owen, P., Wong, L.K., Aebersold, R., Clark-Lewis, I., Jirik, F.R. Biochem. J. (1994) [Pubmed]
  17. Functions of brain chondroitin sulfate proteoglycans during developments: interactions with adhesion molecules. Grumet, M., Friedlander, D.R., Sakurai, T. Perspectives on developmental neurobiology. (1996) [Pubmed]
  18. Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta. Pariser, H., Perez-Pinera, P., Ezquerra, L., Herradon, G., Deuel, T.F. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  19. Increase in receptor-like protein tyrosine phosphatase activity and expression level on density-dependent growth arrest of endothelial cells. Gaits, F., Li, R.Y., Ragab, A., Ragab-Thomas, J.M., Chap, H. Biochem. J. (1995) [Pubmed]
  20. Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents. Seimiya, H., Sawabe, T., Inazawa, J., Tsuruo, T. Oncogene (1995) [Pubmed]
  21. Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Evdokimov, A.G., Pokross, M., Walter, R., Mekel, M., Cox, B., Li, C., Bechard, R., Genbauffe, F., Andrews, R., Diven, C., Howard, B., Rastogi, V., Gray, J., Maier, M., Peters, K.G. Acta Crystallogr. D Biol. Crystallogr. (2006) [Pubmed]
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