High impact information on LIMK1

• Cofilin function in axon growth is inhibited by LIM kinase and activated by Slingshot phosphatase [1].
• LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 [2].
• Together, these findings indicate a link between Rho-LIMK signaling and steroid hormone-induced gene expression in the context of metamorphosis and thereby establish a novel role for the Rho GTPase in development [3].
• We have established a link between Rho-LIMK-SRF signaling and the ecdysone-induced transcriptional response during Drosophila development [3].
• Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis [3].

Anatomical context of LIMK1

• When expressed in cultured cells, wild-type DLIMK, but not its kinase-inactive form, induced changes in actin cytoskeletal organization [4].
• Our findings indicate that LATS1 is a novel cytoskeleton regulator that affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 [2].

Analytical, diagnostic and therapeutic context of LIMK1

• In situ hybridization analysis in Drosophila embryos detected the uniformly distributed DLIMK mRNA in stages 2 to 5 [4].

References