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Gene Review

LATS1  -  large tumor suppressor kinase 1

Homo sapiens

Synonyms: Large tumor suppressor homolog 1, Serine/threonine-protein kinase LATS1, WARTS, WARTS protein kinase, h-warts, ...
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Disease relevance of LATS1


High impact information on LATS1

  • The tumor suppressors Merlin, expanded, hippo, salvador and mob as tumor suppressor also share multiple Fat pathway phenotypes but regulate Warts activity independently [4].
  • One of the genes we identified is the large tumour suppressor gene, lats (also known as wts), which encodes a putative serine/threonine kinase [5].
  • Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction [3].
  • Furthermore, Lats1-/- mice develop soft-tissue sarcomas and ovarian stromal cell tumours and are highly sensitive to carcinogenic treatments [3].
  • Sustained activation of ROS-PKCdelta signalling irreversibly blocks cytokinesis, at least partly through reducing the level of WARTS (also known as LATS1), a mitotic exit network (MEN) kinase required for cytokinesis, in human senescent cells [6].

Chemical compound and disease context of LATS1

  • LATS was measured with the double isotope technique in IgG serum concentrates of 23 patients with Graves' disease before treatment and of 18 patients during treatment with carbimazole and triiodothyronine [7].
  • Serum thyroid-stimulating autoantibodies (LATS and LATS protector) and thyrotropin (TSH) concentrations were measured in the serum of 30 patients with hyperthyroidism living in Tasmania who developed their disease following correction of iodine deficiency by addition of iodate to the bread [8].
  • Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2 [9].
  • External genital warts: report of the American Medical Association Consensus Conference. AMA Expert Panel on External Genital Warts [10].
  • Two full-size transcripts with mol. wts. of 0.74 and 0.66 X 10(6) (2.2 kb and 2 kb, respectively) were synthesized by the virus-associated RNA-dependent RNA polymerase and resolved by denaturing polyacrylamide gel electrophoresis [11].

Biological context of LATS1


Anatomical context of LATS1


Associations of LATS1 with chemical compounds

  • On the basis of the deduced amino acid sequences and compositions and the mol. wts. of their encoded glycoproteins, the genes, dlec1 and dlec2, are predicted to encode erythro- and leucoagglutinating phytohemagglutinins (PHA-E and PHA-L), respectively [20].
  • Nitrate influx via the low-affinity transport system (LATS) was unaffected [21].
  • The serum or IgG fraction from one of them, however, did not contain any significant LATS, LATS-protector, or human thyroid adenylate cyclase-stimulating activity and caused inhibition of adenylate cyclase stimulation by TSH [22].
  • No difference could be found in the mean values of total thyroxine, thyroid 131-I uptake and thyroid weight of the group of LATS positive and LATS negative patients before treatment [7].
  • After pretreatment with 2-mercaptoethanol and sodium dodecyl sulphate, alpha-D-mannosidase dissociated into subunits of mol. wts. of 58 000 +/- 600 and 30 000 +/- 380 respectively [23].

Regulatory relationships of LATS1


Other interactions of LATS1


Analytical, diagnostic and therapeutic context of LATS1


  1. LATS1 tumor suppressor regulates G2/M transition and apoptosis. Xia, H., Qi, H., Li, Y., Pei, J., Barton, J., Blackstad, M., Xu, T., Tao, W. Oncogene (2002) [Pubmed]
  2. Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. Hisaoka, M., Tanaka, A., Hashimoto, H. Lab. Invest. (2002) [Pubmed]
  3. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. St John, M.A., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M.L., Brownstein, D.G., Parlow, A.F., McGrath, J., Xu, T. Nat. Genet. (1999) [Pubmed]
  4. Delineation of a Fat tumor suppressor pathway. Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R., Irvine, K.D. Nat. Genet. (2006) [Pubmed]
  5. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Tao, W., Zhang, S., Turenchalk, G.S., Stewart, R.A., St John, M.A., Chen, W., Xu, T. Nat. Genet. (1999) [Pubmed]
  6. Mitogenic signalling and the p16(INK4a)-Rb pathway cooperate to enforce irreversible cellular senescence. Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E. Nat. Cell Biol. (2006) [Pubmed]
  7. Dissociation of serum LATS activity and hyperfunction and autonomy of the thyroid gland in Graves' disease. Hennemann, G., Dolman, A., Docter, R., De Reus, A., Van Zijl, J. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  8. Hyperthyroidism in Tasmania following iodide supplementation: measurements of thyroid-stimulating autoantibodies and thyrotropin. Adams, D.D., Kennedy, T.H., Stewart, J.C., Utiger, R.D., Vidor, G.I. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  9. Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. Smallridge, R.C., Wartofsky, L., Chopra, I.J., Marinelli, P.V., Broughton, R.E., Dimond, R.C., Burman, K.D. J. Pediatr. (1978) [Pubmed]
  10. External genital warts: report of the American Medical Association Consensus Conference. AMA Expert Panel on External Genital Warts. Beutner, K.R., Reitano, M.V., Richwald, G.A., Wiley, D.J. Clin. Infect. Dis. (1998) [Pubmed]
  11. Transcription and in vitro translation of the dsRNA virus isolated from Rhizoctonia solani. Finkler, A., Ben-Zvi, B.S., Koltin, Y., Barash, I. Virus Genes (1988) [Pubmed]
  12. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Yang, X., Yu, K., Hao, Y., Li, D.M., Stewart, R., Insogna, K.L., Xu, T. Nat. Cell Biol. (2004) [Pubmed]
  13. Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. Hirota, T., Morisaki, T., Nishiyama, Y., Marumoto, T., Tada, K., Hara, T., Masuko, N., Inagaki, M., Hatakeyama, K., Saya, H. J. Cell Biol. (2000) [Pubmed]
  14. Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis. Yang, X., Li, D.M., Chen, W., Xu, T. Oncogene (2001) [Pubmed]
  15. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Chan, E.H., Nousiainen, M., Chalamalasetty, R.B., Schäfer, A., Nigg, E.A., Silljé, H.H. Oncogene (2005) [Pubmed]
  16. Human LATS1 is a mitotic exit network kinase. Bothos, J., Tuttle, R.L., Ottey, M., Luca, F.C., Halazonetis, T.D. Cancer Res. (2005) [Pubmed]
  17. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Hergovich, A., Schmitz, D., Hemmings, B.A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  18. A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. Nishiyama, Y., Hirota, T., Morisaki, T., Hara, T., Marumoto, T., Iida, S., Makino, K., Yamamoto, H., Hiraoka, T., Kitamura, N., Saya, H. FEBS Lett. (1999) [Pubmed]
  19. Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. Comoglio, P.M., Di Renzo, M.F., Tarone, G., Giancotti, F.G., Naldini, L., Marchisio, P.C. EMBO J. (1984) [Pubmed]
  20. Characterization of two Phaseolus vulgaris phytohemagglutinin genes closely linked on the chromosome. Hoffman, L.M., Donaldson, D.D. EMBO J. (1985) [Pubmed]
  21. Dissection of the AtNRT2.1:AtNRT2.2 Inducible High-Affinity Nitrate Transporter Gene Cluster. Li, W., Wang, Y., Okamoto, M., Crawford, N.M., Siddiqi, M.Y., Glass, A.D. Plant Physiol. (2007) [Pubmed]
  22. Detection and properties of TSH-binding inhibitor immunoglobulins in patients with Graves' disease and Hashimoto's thyroiditis. Endo, K., Kasagi, K., Konishi, J., Ikekubo, K., Okuno, T., Takeda, Y., Mori, T., Torizuka, K. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  23. Isolation and properties of alpha-D-mannosidase from human kidney. Marinkovic, D.V., Marinkovic, J.N. Biochem. J. (1976) [Pubmed]
  24. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. Hao, Y., Chun, A., Cheung, K., Rashidi, B., Yang, X. J. Biol. Chem. (2008) [Pubmed]
  25. Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Takahashi, Y., Miyoshi, Y., Takahata, C., Irahara, N., Taguchi, T., Tamaki, Y., Noguchi, S. Clin. Cancer Res. (2005) [Pubmed]
  26. NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis. Tamaskovic, R., Bichsel, S.J., Hemmings, B.A. FEBS Lett. (2003) [Pubmed]
  27. Allelic imbalance in selected chromosomal regions in ovarian cancer. Hansen, L.L., Jensen, L.L., Dimitrakakis, C., Michalas, S., Gilbert, F., Barber, H.R., Overgaard, J., Arzimanoglou, I.I. Cancer Genet. Cytogenet. (2002) [Pubmed]
  28. Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma. Rutherford, S., Yu, Y., Rumpel, C.A., Frierson, H.F., Moskaluk, C.A. Cancer Lett. (2006) [Pubmed]
  29. The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B cells. Swendeman, S., Thorley-Lawson, D.A. EMBO J. (1987) [Pubmed]
  30. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. Hori, T., Takaori-Kondo, A., Kamikubo, Y., Uchiyama, T. Oncogene (2000) [Pubmed]
  31. Zoological specificity of human thyroid-stimulating antibody. Zakarija, M., McKenzie, J.M. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
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