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Gene Review

hiw  -  highwire

Drosophila melanogaster

Synonyms: CG32592, CG9041, CG9049, Dmel\CG32592, E3 ubiquitin-protein ligase highwire, ...
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High impact information on hiw

  • These results suggest that Highwire controls structural plasticity of the synapse by regulating gene expression through a MAP kinase signaling pathway [1].
  • Here we show that Hiw binds to the Smad protein Medea (Med) [2].
  • Highwire regulates presynaptic BMP signaling essential for synaptic growth [2].
  • These synapses appear normal ultrastructurally but have reduced quantal content physiologically. hiw encodes a large protein found at presynaptic terminals [3].
  • RPM-1 is most similar to the Drosophila presynaptic protein Highwire (HIW) and the mammalian Myc binding protein Pam [4].

Biological context of hiw


Anatomical context of hiw


Other interactions of hiw

  • These results reveal a balance between positive BMP signaling and negative regulation by Highwire, governing the growth of neuromuscular synapses [2].
  • Current models of highwire function suggest that it may act as a ubiquitin ligase to regulate synaptic development [5].
  • Fat facets does a Highwire act at the synapse [6].


  1. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Collins, C.A., Wairkar, Y.P., Johnson, S.L., DiAntonio, A. Neuron (2006) [Pubmed]
  2. Highwire regulates presynaptic BMP signaling essential for synaptic growth. McCabe, B.D., Hom, S., Aberle, H., Fetter, R.D., Marques, G., Haerry, T.E., Wan, H., O'Connor, M.B., Goodman, C.S., Haghighi, A.P. Neuron (2004) [Pubmed]
  3. Highwire regulates synaptic growth in Drosophila. Wan, H.I., DiAntonio, A., Fetter, R.D., Bergstrom, K., Strauss, R., Goodman, C.S. Neuron (2000) [Pubmed]
  4. Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Zhen, M., Huang, X., Bamber, B., Jin, Y. Neuron (2000) [Pubmed]
  5. Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements. Wu, C., Wairkar, Y.P., Collins, C.A., DiAntonio, A. J. Neurosci. (2005) [Pubmed]
  6. Fat facets does a Highwire act at the synapse. Fischer, J.A., Overstreet, E. Bioessays (2002) [Pubmed]
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