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Gene Review

faf  -  fat facets

Drosophila melanogaster

Synonyms: BcDNA.LD22582, BcDNA:LD22582, CG1945, Deubiquitinating enzyme FAF, Dmel\CG1945, ...
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High impact information on faf


Biological context of faf

  • Fat facets is a Drosophila deubiquitinating enzyme required for eye development and early embryogenesis [6].
  • In a screen for mutations affecting Drosophila eye development, we have identified a gene called fat facets (faf) which is required for cell interactions that prevent particular cells in the developing eye from becoming photoreceptors [5].
  • Fat facets belongs to a class of deubiquitinating enzymes called Ubps that share a conserved catalytic domain [7].
  • In a mutagenesis screen for suppressors of the fat facets (faf) mutant eye phenotype, we identified mutations in DNAprim [8].
  • We show that while flies lacking DNAprim activity are lethal, flies with reduced DNAprim activity display morphological defects in their eyes, and unlike faf mutants, cell cycle abnormalities in larval eye discs [8].

Anatomical context of faf

  • Prominent among these proteins was the ubiquitin-specific protease Fat facets (FAF), a pole plasm component [7], but one whose roles in posterior patterning and germ line specification have remained unclear [9].

Regulatory relationships of faf


Other interactions of faf

  • We found no genetic evidence to support a role for either Canoe or Armadillo in the essential Fat facets pathways in Drosophila eye development [6].
  • Consistently, the protein level of at least one component of the Ras signal transduction pathway, the transcription factor D-Jun, is elevated in faf eye discs at the time when the ectopic photoreceptors are induced [10].


  1. A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. Chen, X., Zhang, B., Fischer, J.A. Genes Dev. (2002) [Pubmed]
  2. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Wing, J.P., Schreader, B.A., Yokokura, T., Wang, Y., Andrews, P.S., Huseinovic, N., Dong, C.K., Ogdahl, J.L., Schwartz, L.M., White, K., Nambu, J.R. Nat. Cell Biol. (2002) [Pubmed]
  3. Fat facets does a Highwire act at the synapse. Fischer, J.A., Overstreet, E. Bioessays (2002) [Pubmed]
  4. The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. Cadavid, A.L., Ginzel, A., Fischer, J.A. Development (2000) [Pubmed]
  5. The fat facets gene is required for Drosophila eye and embryo development. Fischer-Vize, J.A., Rubin, G.M., Lehmann, R. Development (1992) [Pubmed]
  6. On the conservation of function of the Drosophila fat facets deubiquitinating enzyme and Fam, its mouse homolog. Chen, X., Overstreet, E., Wood, S.A., Fischer, J.A. Dev. Genes Evol. (2000) [Pubmed]
  7. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen, X., Fischer, J.A. Genetics (2000) [Pubmed]
  8. Genetic analysis of the Drosophila DNAprim gene. The function of the 60-kd primase subunit of DNA polymerase opposes the fat facets signaling pathway in the developing eye. Chen, X., Li, Q., Fischer, J.A. Genetics (2000) [Pubmed]
  9. Fat facets interacts with vasa in the Drosophila pole plasm and protects it from degradation. Liu, N., Dansereau, D.A., Lasko, P. Curr. Biol. (2003) [Pubmed]
  10. The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development. Isaksson, A., Peverali, F.A., Kockel, L., Mlodzik, M., Bohmann, D. Mech. Dev. (1997) [Pubmed]
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