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Gene Review

mycbp2  -  MYC binding protein 2

Danio rerio

Synonyms: Myc, PAM, SO:0000704, esr, esrom, ...
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Disease relevance of mycbp2

  • To test the ability of bcl-2 to block irradiation-induced apoptosis in malignant cells, we compared the responsiveness of Myc-induced leukemias with and without EGFP-bcl-2 expression in living transgenic zebrafish [1].

High impact information on mycbp2

  • T-cell leukemias induced by the rag2-EGFP-Myc transgene were ablated by irradiation, whereas leukemias in double transgenic fish expressing both Myc and EGFP-bcl-2 were resistant to irradiation-induced apoptotic cell death [1].
  • We show here that Esrom has E3 ligase activity and modulates the amount of phosphorylated Tuberin, a tumor suppressor, in growth cones [2].
  • Esrom has recently been identified as an ortholog of PAM (protein associated with c-myc), a very large protein involved in synaptogenesis in Drosophila and C. elegans [3].
  • These data thus introduce a new regulator of pteridine synthesis in a vertebrate and establish a function for the Esrom protein family outside synaptogenesis [3].
  • Importantly, the cofactor tetrahydrobiopterin (BH4) is drastically reduced in esrom mutants [3].

Biological context of mycbp2


  1. Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Langenau, D.M., Jette, C., Berghmans, S., Palomero, T., Kanki, J.P., Kutok, J.L., Look, A.T. Blood (2005) [Pubmed]
  2. Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc). D'Souza, J., Hendricks, M., Le Guyader, S., Subburaju, S., Grunewald, B., Scholich, K., Jesuthasan, S. Development (2005) [Pubmed]
  3. Esrom, an ortholog of PAM (protein associated with c-myc), regulates pteridine synthesis in the zebrafish. Le Guyader, S., Maier, J., Jesuthasan, S. Dev. Biol. (2005) [Pubmed]
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