The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MYCBP2  -  MYC binding protein 2, E3 ubiquitin...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase MYCBP2, FLJ10106, KIAA0916, Myc-binding protein 2, PAM, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MYCBP2


Psychiatry related information on MYCBP2

  • The average psychometric curve revealed that the threshold for PAM detection was 314 degrees /s. The minimum and maximum thresholds for individual subjects were 277 degrees and 378 degrees /s, respectively [6].
  • At posttreatment, results indicated that within the child-anxiety-only condition, 82% of the children in the CBT condition no longer met criteria for an anxiety disorder compared with 80% in the CBT + PAM condition [7].

High impact information on MYCBP2


Chemical compound and disease context of MYCBP2


Biological context of MYCBP2

  • A radiolabeled proteolytic plasminogen fragment containing the first three kringles (K1-K3) interacted with streptococci expressing PAM or a chimeric surface protein harboring the a1a2 sequence [11].
  • The DNA sequence data also proved the relationship of the encoded protein, named PAM, to the M proteins [2].
  • Here, we describe the relationship between plasminogen-binding capacity of GAS isolates, PAM genotype, and invasive capacity in 29 GAS isolates belonging to 25 distinct strains from the NT [12].
  • Despite considerable amino acid sequence variation within the A1 repeat region of PAM where the plasminogen-binding domain maps, the critical lysine residue was conserved [12].
  • RESULTS: We apply our analysis to the comparative study of amino acid substitution matrix families and find that using modern matrices results in a small, but statistically significant improvement in remote homology detection compared with the classic PAM and BLOSUM matrices [13].

Anatomical context of MYCBP2

  • The gene encoding Pam (PAM) is expressed in all of the human tissue examined, but expression is exceptionally abundant in brain and thymus [9].
  • Coexpression of ACV and full-length PAM or its N-terminal third (PAM-N) in COS-7 cells inhibited isoproterenol-stimulated cAMP accumulation [14].
  • Here, we demonstrate that PAM mRNA is highly expressed in specific anatomical regions including hippocampus, dentate gyrus and cerebellum [15].
  • In these areas, PAM mRNA is restricted to pyramidal cells of hippocampus and granule cells of dentate gyrus and cerebellum [15].
  • These results demonstrate for the first time a bidirectional activating interaction between iDCs and PAM-stimulated gammadelta T lymphocytes, thus suggesting a potential adjuvant role of this early cross-talk in the therapeutic activity of aminobiphosphonate drugs [16].

Associations of MYCBP2 with chemical compounds

  • PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate [8].
  • We reported previously that protein associated with Myc (PAM) interacts with the C2 domain of type V adenylyl cyclase (ACV-C2) and that purified PAM is a potent inhibitor of Galphas-stimulated ACV activity (J Biol Chem 276:47583-47589, 2001) [14].
  • Collateral sensitivity of the G3361/CP, G3361/PAM, and G3361/4HC lines to killing by BCNU was also observed [17].
  • The insertion of an alanine between Pro-1 and Met-2 (PAM) abolishes a non-physiological catalytic activity, and this mutant is defective in the in vitro glucocorticoid counter-regulatory activity of MIF [18].
  • In contrast, plasminogen fragments containing kringle 4 or kringle 5 and the activable serine proteinase domain failed to bind to PAM-expressing group A streptococci [11].

Other interactions of MYCBP2

  • Developmental expression of PAM (protein associated with MYC) in the rodent brain [15].

Analytical, diagnostic and therapeutic context of MYCBP2

  • Expression patterns of PAM in both rat and mouse brains were examined by using in situ hybridization [15].
  • Using the yeast two-hybrid assay and the second of the two large cytosolic domains of type V adenylyl cyclase (ACV) as bait, we identified a small region (amino acids 1028-1231) in the protein associated with Myc (PAM) as an interaction site for ACV [19].
  • Two-dimensional gel electrophoresis identified 13 different proteins migrating at 60 kDa; 5 were splice variants of HSP60, and 2 corresponded with a protein associated with MYC (PAM) [20].
  • Expression of a plasminogen-binding GAS M-like protein (PAM) has been associated with skin infection in isolates elsewhere (D. Bessen, C. M. Sotir, T. M. Readdy, and S. K. Hollingshead, J. Infect. Dis. 173:896-900, 1996), and subversion of the host plasminogen system by GAS is thought to contribute to invasion in animal models [12].
  • In order to assess the potential phytotoxic impact of herbicide residues in the estuaries, surface waters were analysed with a PAM fluorometry-based bioassay that employs the photosynthetic efficiency (photosystem II quantum yield) of laboratory cultured microalgae, as an endpoint measure of phytotoxicity [21].


  1. Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine. Slovin, S.F., Ragupathi, G., Musselli, C., Olkiewicz, K., Verbel, D., Kuduk, S.D., Schwarz, J.B., Sames, D., Danishefsky, S., Livingston, P.O., Scher, H.I. J. Clin. Oncol. (2003) [Pubmed]
  2. PAM, a novel plasminogen-binding protein from Streptococcus pyogenes. Berge, A., Sjöbring, U. J. Biol. Chem. (1993) [Pubmed]
  3. Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators. Xue, S.Z., Ding, X.J., Ding, Y. Scandinavian journal of work, environment & health. (1985) [Pubmed]
  4. Media for the detection and recognition of the enteropathogen Providencia alcalifaciens in faeces. Senior, B.W. J. Med. Microbiol. (1997) [Pubmed]
  5. Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells. Hromas, R.A., Andrews, P.A., Murphy, M.P., Burns, C.P. Cancer Lett. (1987) [Pubmed]
  6. Decoding of path-guided apparent motion from neural ensembles in posterior parietal cortex. Merchant, H., Battaglia-Mayer, A., Georgopoulos, A.P. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2005) [Pubmed]
  7. The role of parental anxiety in the treatment of childhood anxiety. Cobham, V.E., Dadds, M.R., Spence, S.H. Journal of consulting and clinical psychology. (1998) [Pubmed]
  8. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. Pierre, S.C., Häusler, J., Birod, K., Geisslinger, G., Scholich, K. EMBO J. (2004) [Pubmed]
  9. Identification of a large Myc-binding protein that contains RCC1-like repeats. Guo, Q., Xie, J., Dang, C.V., Liu, E.T., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. The treatment of ovarian cancer by a multimodality approach: remission induction with chemotherapy--hexa PAMP and PAMP regimens--followed by whole-abdominal radiation. Goldhirsch, A., Greiner, R., Dreher, E., Locher, G., Davis, B.W., Reinhard, J.P., Joss, R., Brunner, K.W. Onkologie. (1985) [Pubmed]
  11. Kringle 2 mediates high affinity binding of plasminogen to an internal sequence in streptococcal surface protein PAM. Wistedt, A.C., Kotarsky, H., Marti, D., Ringdahl, U., Castellino, F.J., Schaller, J., Sjöbring, U. J. Biol. Chem. (1998) [Pubmed]
  12. Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection. McKay, F.C., McArthur, J.D., Sanderson-Smith, M.L., Gardam, S., Currie, B.J., Sriprakash, K.S., Fagan, P.K., Towers, R.J., Batzloff, M.R., Chhatwal, G.S., Ranson, M., Walker, M.J. Infect. Immun. (2004) [Pubmed]
  13. Statistical evaluation of pairwise protein sequence comparison with the Bayesian bootstrap. Price, G.A., Crooks, G.E., Green, R.E., Brenner, S.E. Bioinformatics (2005) [Pubmed]
  14. Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity. Gao, X., Patel, T.B. Mol. Pharmacol. (2005) [Pubmed]
  15. Developmental expression of PAM (protein associated with MYC) in the rodent brain. Yang, H., Scholich, K., Poser, S., Storm, D.R., Patel, T.B., Goldowitz, D. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  16. Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines. Conti, L., Casetti, R., Cardone, M., Varano, B., Martino, A., Belardelli, F., Poccia, F., Gessani, S. J. Immunol. (2005) [Pubmed]
  17. Cross-resistance and glutathione-S-transferase-pi levels among four human melanoma cell lines selected for alkylating agent resistance. Wang, Y.Y., Teicher, B.A., Shea, T.C., Holden, S.A., Rosbe, K.W., al-Achi, A., Henner, W.D. Cancer Res. (1989) [Pubmed]
  18. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. Lubetsky, J.B., Dios, A., Han, J., Aljabari, B., Ruzsicska, B., Mitchell, R., Lolis, E., Al-Abed, Y. J. Biol. Chem. (2002) [Pubmed]
  19. Protein associated with Myc (PAM) is a potent inhibitor of adenylyl cyclases. Scholich, K., Pierre, S., Patel, T.B. J. Biol. Chem. (2001) [Pubmed]
  20. Studies characterizing 60 kda autoantibodies in subjects with schizophrenia. Wang, X.F., Wang, D., Zhu, W., Delrahim, K.K., Dolnak, D., Rapaport, M.H. Biol. Psychiatry (2003) [Pubmed]
  21. Phytotoxicity of surface waters of the Thames and Brisbane River Estuaries: A combined chemical analysis and bioassay approach for the comparison of two systems. Bengtson Nash, S.M., Goddard, J., Müller, J.F. Biosensors & bioelectronics. (2006) [Pubmed]
WikiGenes - Universities