High impact information on SPAC664.15

• Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18 [1].
• The mip1 gene encoded a protein of 1,313 amino acids which carried a WD-repeat motif in the C-terminal region and was apparently conserved among eukaryotes [2].
• In vitro glutathione S-transferase pull-down experiments revealed that Pct1 binds to the WD repeat regions of Tup11 and the functionally redundant Tup12 protein [3].
• Our study thus provides evidence for a possible role of WD repeat-containing TAFs in the expression of genes involved in progression through the M phase of the cell cycle [4].
• A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes [5].

Biological context of SPAC664.15

• In fission yeast, F-box/WD-repeat protein Pop1 regulates the level of the CDK (cyclin-dependent kinase) inhibitor Rum1 and the S phase regulator Cdc18 [6].
• In this research, one 1156 bp cDNA containing full open reading frame and encoding a novel 24-kDa protein with four tandem WD repeat motifs was cloned from cotton, therefore was named GhWDR and the GenBank accession number is AY870657 [7].

Other interactions of SPAC664.15

• RESULTS: We have cloned and characterized the pop2+ gene which encodes the Pop1-related F-box/WD-repeat protein [6].
• Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase [6].

References