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Gene Review

MDV1  -  Mdv1p

Saccharomyces cerevisiae S288c

Synonyms: FIS2, GAG3, J0802, Mitochondria fission 2 protein, Mitochondrial division protein 1, ...
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Disease relevance of MDV1


High impact information on MDV1

  • The WD40 repeat protein Mdv1/Net2 promotes cell death, consistent with its role in mitochondrial fission [4].
  • Mitochondrial division requires coordinated interactions among Fis1p, Mdv1p, and the Dnm1p GTPase, which assemble into fission complexes on the outer mitochondrial membrane [5].
  • Furthermore, we show that conditional mutations in the Fis1p TPR-like domain cause fission complex assembly defects that are suppressed by mutations in the Mdv1p-predicted coiled coil [5].
  • Here, we show that mitochondrial fragmentation and mitochondrial genome loss caused by lesions in MGM1 are suppressed by three novel mutations, gag1, gag2, and gag3 (for glycerol-adapted growth) [6].
  • Gag3p was localized to mitochondria where it was found to associate as a peripheral protein on the cytosolic face of the outer membrane [6].

Biological context of MDV1


Anatomical context of MDV1

  • Furthermore, our results indicate that Net2p is required for proper assembly of the mitochondrial fission components to regulate organelle division [8].
  • Whereas localization of Mdv1p to these structures requires Dnm1p, localization of Mdv1p to mitochondrial membranes does not [9].

Physical interactions of MDV1


Co-localisations of MDV1

  • In addition, Mdv1p colocalizes with Dnm1p in fission-mediating punctate structures on the mitochondrial outer membrane [9].

Regulatory relationships of MDV1

  • Overproduction of either domain of Net2p in yeast cells poisons mitochondrial fission, and the dominant-negative effect caused by the WD-repeats of Net2p is suppressed by increased levels of Dnm1p [8].

Other interactions of MDV1

  • However, the localization of Dnm1p to the mitochondrial outer membrane is substantially reduced by the gag2 mutation, but unaffected by loss of Gag3p [6].
  • The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria [8].

Analytical, diagnostic and therapeutic context of MDV1


  1. Mutations in the Ty3 major homology region affect multiple steps in Ty3 retrotransposition. Orlinsky, K.J., Gu, J., Hoyt, M., Sandmeyer, S., Menees, T.M. J. Virol. (1996) [Pubmed]
  2. The Cys-His motif of Ty3 NC can be contributed by Gag3 or Gag3-Pol3 polyproteins. Orlinsky, K.J., Sandmeyer, S.B. J. Virol. (1994) [Pubmed]
  3. Programmed +1 frameshifting stimulated by complementarity between a downstream mRNA sequence and an error-correcting region of rRNA. Li, Z., Stahl, G., Farabaugh, P.J. RNA (2001) [Pubmed]
  4. Mitochondrial fission proteins regulate programmed cell death in yeast. Fannjiang, Y., Cheng, W.C., Lee, S.J., Qi, B., Pevsner, J., McCaffery, J.M., Hill, R.B., Basañez, G., Hardwick, J.M. Genes Dev. (2004) [Pubmed]
  5. The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly. Karren, M.A., Coonrod, E.M., Anderson, T.K., Shaw, J.M. J. Cell Biol. (2005) [Pubmed]
  6. Gag3p, an outer membrane protein required for fission of mitochondrial tubules. Fekkes, P., Shepard, K.A., Yaffe, M.P. J. Cell Biol. (2000) [Pubmed]
  7. Division of mitochondria requires a novel DMN1-interacting protein, Net2p. Cerveny, K.L., McCaffery, J.M., Jensen, R.E. Mol. Biol. Cell (2001) [Pubmed]
  8. The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria. Cerveny, K.L., Jensen, R.E. Mol. Biol. Cell (2003) [Pubmed]
  9. Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. Tieu, Q., Nunnari, J. J. Cell Biol. (2000) [Pubmed]
  10. Proteolytic processing of Ty3 proteins is required for transposition. Kirchner, J., Sandmeyer, S. J. Virol. (1993) [Pubmed]
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