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Gene Review

Psyr_1395  -  virulence

Pseudomonas syringae pv. syringae B728a

 
 
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Disease relevance of Psyr_1395

  • Involvement of the exopolysaccharide alginate in the virulence and epiphytic fitness of Pseudomonas syringae pv. syringae [1].
  • Tn5 insertion mutants of Xanthomonas campestris pv. vesicatoria were inoculated into tomato and screened for reduced virulence [2].
 

High impact information on Psyr_1395

  • Although a high degree of similarity exists between the two sequenced Pseudomonads, 976 protein-encoding genes are unique to Pss B728a when compared with Pst DC3000, including large genomic islands likely to contribute to virulence and host specificity [3].
  • Alginate, a co-polymer of O-acetylated beta-1,4-linked D-mannuronic acid and L-guluronic acid, has been reported to function in the virulence of Pseudomonas syringae, although genetic studies to test this hypothesis have not been undertaken previously [1].
  • Previous studies revealed that salA, a member of the GacS/GacA signal transduction system, was required for bacterial virulence, syringomycin production, and expression of the syrB1 synthetase gene [4].
  • To define the SalA regulon, the spotted oligonucleotide microarray was constructed using gene-specific 70-mer oligonucleotides of all open reading frames (ORFs) predicted in the syringomycin (syr) and syringopeptin (syp) gene clusters along with representative genes important to bacterial virulence, growth, and survival [4].
  • Together, the syr and syp gene clusters encompass approximately 135 kb of DNA and may represent a genomic island in P. syringae pv. syringae that contributes to virulence in plant hosts [5].
 

Biological context of Psyr_1395

  • These results suggest that the syrP gene encodes a regulatory protein that participates in a phosphorylation cascade controlling syringomycin production and virulence in P. syringae pv. syringae [6].
  • Homologous recombination of the genes required for syringomycin production from cosmids pGX183 (syrA) and pGX56 (syrB), respectively, introduced into nontoxigenic (Tox-) Tn5 mutants W4S2545 and W4S770 resulted in the concomitant restoration of toxin production and full virulence [7].
  • Thus, excretion of pyoverdinpss and subsequent Fe(III) uptake do not have a determinative role in the pathogenicity or virulence of P. syringae pv. syringae [8].

References

  1. Involvement of the exopolysaccharide alginate in the virulence and epiphytic fitness of Pseudomonas syringae pv. syringae. Yu, J., Peñaloza-Vázquez, A., Chakrabarty, A.M., Bender, C.L. Mol. Microbiol. (1999) [Pubmed]
  2. Importance of opgHXcv of Xanthomonas campestris pv. vesicatoria in host-parasite interactions. Minsavage, G.V., Mudgett, M.B., Stall, R.E., Jones, J.B. Mol. Plant Microbe Interact. (2004) [Pubmed]
  3. Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000. Feil, H., Feil, W.S., Chain, P., Larimer, F., DiBartolo, G., Copeland, A., Lykidis, A., Trong, S., Nolan, M., Goltsman, E., Thiel, J., Malfatti, S., Loper, J.E., Lapidus, A., Detter, J.C., Land, M., Richardson, P.M., Kyrpides, N.C., Ivanova, N., Lindow, S.E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Oligonucleotide microarray analysis of the salA regulon controlling phytotoxin production by Pseudomonas syringae pv. syringae. Lu, S.E., Wang, N., Wang, J., Chen, Z.J., Gross, D.C. Mol. Plant Microbe Interact. (2005) [Pubmed]
  5. A physical map of the syringomycin and syringopeptin gene clusters localized to an approximately 145-kb DNA region of Pseudomonas syringae pv. syringae strain B301D. Scholz-Schroeder, B.K., Soule, J.D., Lu, S.E., Grgurina, I., Gross, D.C. Mol. Plant Microbe Interact. (2001) [Pubmed]
  6. Analysis of the syrP gene, which regulates syringomycin synthesis by Pseudomonas syringae pv. syringae. Zhang, J.H., Quigley, N.B., Gross, D.C. Appl. Environ. Microbiol. (1997) [Pubmed]
  7. Physical and functional analyses of the syrA and syrB genes involved in syringomycin production by Pseudomonas syringae pv. syringae. Xu, G.W., Gross, D.C. J. Bacteriol. (1988) [Pubmed]
  8. Outer membrane protein mediating iron uptake via pyoverdinpss, the fluorescent siderophore produced by Pseudomonas syringae pv. syringae. Cody, Y.S., Gross, D.C. J. Bacteriol. (1987) [Pubmed]
 
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