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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ARHGDIA  -  Rho GDP dissociation inhibitor (GDI) alpha

Bos taurus

 
 
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Disease relevance of ARHGDIA

 

High impact information on ARHGDIA

  • We have investigated the effects of Rho GDP dissociation inhibitor (RhoGDI) on exocytosis induced by guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) in rat mast cells, introducing the protein into cells by means of a patch pipette and recording the progress of exocytosis by monitoring cell capacitance [2].
  • Ventricular myocytes isolated from transgenic (TG) mice that overexpress the specific GDP dissociation inhibitor Rho GDI-alpha exhibited significantly decreased basal L-type Ca2+ current density (approximately 40%) compared with myocytes from nontransgenic (NTG) mice [3].
  • When the protein was delivered directly into adult ventricular myocytes via TAT-mediated protein transduction, Rho GDI-alpha significantly decreased Ca2+ current density, which supports the idea that the defective Ca2+ channel activity in TG myocytes was a primary effect of the transgene [3].
  • Solubilization of Cdc42Hs from membranes by Rho-GDP dissociation inhibitor [4].

References

  1. Copurification of rho protein and the rho-GDP dissociation inhibitor from bovine neutrophil cytosol. Effect of phosphoinositides on rho ADP-ribosylation by the C3 exoenzyme of Clostridium botulinum. Bourmeyster, N., Stasia, M.J., Garin, J., Gagnon, J., Boquet, P., Vignais, P.V. Biochemistry (1992) [Pubmed]
  2. Rho guanine nucleotide dissociation inhibitor protein (RhoGDI) inhibits exocytosis in mast cells. Mariot, P., O'Sullivan, A.J., Brown, A.M., Tatham, P.E. EMBO J. (1996) [Pubmed]
  3. RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes. Yatani, A., Irie, K., Otani, T., Abdellatif, M., Wei, L. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  4. Solubilization of Cdc42Hs from membranes by Rho-GDP dissociation inhibitor. Leonard, D.A., Cerione, R.A. Meth. Enzymol. (1995) [Pubmed]
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