Gene Review:
Arhgdia - Rho GDP dissociation inhibitor (GDI) alpha
Mus musculus
Synonyms:
5330430M07Rik, C87222, GDI-1, Gdi-1, Gdi1, ...
Del Pozo,
Kiosses,
Alderson,
Meller,
Hahn,
Schwartz,
Abell,
DeCathelineau,
Weed,
Ambruso,
Riches,
Johnson,
Genth,
Gerhard,
Maeda,
Amano,
Kaibuchi,
Aktories,
Just,
Kumar,
Murphy,
Robinson,
Wei,
Boriek,
Wei,
Taffet,
Khoury,
Bo,
Li,
Yatani,
Delaughter,
Klevitsky,
Hewett,
Robbins,
Michael,
Schneider,
Entman,
Schwartz,
- Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Togawa, A., Miyoshi, J., Ishizaki, H., Tanaka, M., Takakura, A., Nishioka, H., Yoshida, H., Doi, T., Mizoguchi, A., Matsuura, N., Niho, Y., Nishimune, Y., Nishikawa, S., Takai, Y. Oncogene (1999)
- Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved. Wei, L., Taffet, G.E., Khoury, D.S., Bo, J., Li, Y., Yatani, A., Delaughter, M.C., Klevitsky, R., Hewett, T.E., Robbins, J., Michael, L.H., Schneider, M.D., Entman, M.L., Schwartz, R.J. FASEB J. (2004)
- Human RhoA/RhoGDI complex expressed in yeast: GTP exchange is sufficient for translocation of RhoA to liposomes. Read, P.W., Liu, X., Longenecker, K., Dipierro, C.G., Walker, L.A., Somlyo, A.V., Somlyo, A.P., Nakamoto, R.K. Protein Sci. (2000)
- ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Allenspach, E.J., Cullinan, P., Tong, J., Tang, Q., Tesciuba, A.G., Cannon, J.L., Takahashi, S.M., Morgan, R., Burkhardt, J.K., Sperling, A.I. Immunity (2001)
- The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Yamashita, T., Tohyama, M. Nat. Neurosci. (2003)
- Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Del Pozo, M.A., Kiosses, W.B., Alderson, N.B., Meller, N., Hahn, K.M., Schwartz, M.A. Nat. Cell Biol. (2002)
- Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. Michaelson, D., Silletti, J., Murphy, G., D'Eustachio, P., Rush, M., Philips, M.R. J. Cell Biol. (2001)
- Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Wei, L., Imanaka-Yoshida, K., Wang, L., Zhan, S., Schneider, M.D., DeMayo, F.J., Schwartz, R.J. Development (2002)
- Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL. Unwin, R.D., Sternberg, D.W., Lu, Y., Pierce, A., Gilliland, D.G., Whetton, A.D. J. Biol. Chem. (2005)
- Defective Chemokine-Directed Lymphocyte Migration and Development in the Absence of Rho Guanosine Diphosphate-Dissociation Inhibitors {alpha} and beta. Ishizaki, H., Togawa, A., Tanaka-Okamoto, M., Hori, K., Nishimura, M., Hamaguchi, A., Imai, T., Takai, Y., Miyoshi, J. J. Immunol. (2006)
- Characterization of Rho-GDIgamma and Rho-GDIalpha mRNA in the developing and mature brain with an analysis of mice with targeted deletions of Rho-GDIgamma. Ferland, R.J., Li, X., Buhlmann, J.E., Bu, X., Walsh, C.A., Lim, B. Brain Res. (2005)
- Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling. Matos, P., Collard, J.G., Jordan, P. J. Biol. Chem. (2003)
- The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin. Wilk-Blaszczak, M.A., Singer, W.D., Quill, T., Miller, B., Frost, J.A., Sternweis, P.C., Belardetti, F. J. Neurosci. (1997)
- Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation. Lakhe-Reddy, S., Khan, S., Konieczkowski, M., Jarad, G., Wu, K.L., Reichardt, L.F., Takai, Y., Bruggeman, L.A., Wang, B., Sedor, J.R., Schelling, J.R. J. Biol. Chem. (2006)
- Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex. Genth, H., Gerhard, R., Maeda, A., Amano, M., Kaibuchi, K., Aktories, K., Just, I. J. Biol. Chem. (2003)
- Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells. Rolli-Derkinderen, M., Sauzeau, V., Boyer, L., Lemichez, E., Baron, C., Henrion, D., Loirand, G., Pacaud, P. Circ. Res. (2005)
- An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells. Gandhi, P.N., Gibson, R.M., Tong, X., Miyoshi, J., Takai, Y., Konieczkowski, M., Sedor, J.R., Wilson-Delfosse, A.L. Biochem. J. (2004)
- RhoGDI is required for Cdc42-mediated cellular transformation. Lin, Q., Fuji, R.N., Yang, W., Cerione, R.A. Curr. Biol. (2003)
- Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Michaelson, D., Ali, W., Chiu, V.K., Bergo, M., Silletti, J., Wright, L., Young, S.G., Philips, M. Mol. Biol. Cell (2005)
- Radixin stimulates Rac1 and Ca2+/calmodulin-dependent kinase, CaMKII: cross-talk with Galpha13 signaling. Liu, G., Voyno-Yasenetskaya, T.A. J. Biol. Chem. (2005)
- Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. Abell, A.N., DeCathelineau, A.M., Weed, S.A., Ambruso, D.R., Riches, D.W., Johnson, G.L. J. Cell. Sci. (2004)
- Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling. Genth, H., Aktories, K., Just, I. J. Biol. Chem. (1999)
- Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-kappaB transcription factor. Kumar, A., Murphy, R., Robinson, P., Wei, L., Boriek, A.M. FASEB J. (2004)
- A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. Platko, J.V., Leonard, D.A., Adra, C.N., Shaw, R.J., Cerione, R.A., Lim, B. Proc. Natl. Acad. Sci. U.S.A. (1995)