The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Submucous Plexus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Submucous Plexus


High impact information on Submucous Plexus


Chemical compound and disease context of Submucous Plexus


Biological context of Submucous Plexus


Anatomical context of Submucous Plexus


Associations of Submucous Plexus with chemical compounds

  • In contrast, the stimulus-induced expression of Fos immunoreactivity was inhibited, but not abolished, by hexamethonium, which limited the spread of activation within the submucosal plexus and completely prevented expression of Fos immunoreactivity by myenteric neurons in response to mucosal puffs of N2 [19].
  • 6. The results show that the hyperpolarization of submucosal plexus neurones by noradrenaline, somatostatin and [Met5]enkephalin results from the increased opening of at least three types of background potassium channel, and that the coupling from the receptors to the channels is maintained in excised membrane patches [20].
  • Synchronized discharges of stretch-activated EJPs and IJPs were preserved following pretreatment with capsaicin (10 microM), were unaffected by nifedipine (1 microM) and did not require the mucosa or submucous plexus [21].
  • 2. Cocaine (0.2-30 microM) reversibly increased the duration of the i.p.s.p. or inhibitory post-synaptic current (i.p.s.c.) in locus coeruleus neurones and submucous plexus neurones by approximately 750% and 350% respectively [22].
  • 6-hydroxydopamine selectively and irreversibly abolished the i.p.s.p. and resulted in a complete loss of catecholamine fluorescent nerve fibres in the submucous plexus [23].

Gene context of Submucous Plexus


Analytical, diagnostic and therapeutic context of Submucous Plexus


  1. Localisation of endothelin like immunoreactivity in adult and developing human gut. Escrig, C., Bishop, A.E., Inagaki, H., Moscoso, G., Takahashi, K., Varndell, I.M., Ghatei, M.A., Bloom, S.R., Polak, J.M. Gut (1992) [Pubmed]
  2. Role of the enteric nervous system in the maintained hypersecretion induced by enterotoxin STa in the nutritionally deprived intestine. Nzegwu, H.C., Levin, R.J. Gut (1994) [Pubmed]
  3. Terminal ileum submucous plexus: Study of the VIP-ergic neurons of diabetic rats treated with ascorbic acid. Zanoni, J.N., Hernandes, L., Bazotte, R.B., Miranda Neto, M.H. Arquivos de neuro-psiquiatria. (2002) [Pubmed]
  4. Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors. Michel, K., Zeller, F., Langer, R., Nekarda, H., Kruger, D., Dover, T.J., Brady, C.A., Barnes, N.M., Schemann, M. Gastroenterology (2005) [Pubmed]
  5. Neural sites of the human colon colocalize nitric oxide synthase-related NADPH diaphorase activity and neuropeptide Y. Nichols, K., Staines, W., Krantis, A. Gastroenterology (1994) [Pubmed]
  6. Peptide-containing neurons in different regions of the submucous plexus of human sigmoid colon. Crowe, R., Kamm, M.A., Burnstock, G., Lennard-Jones, J.E. Gastroenterology (1992) [Pubmed]
  7. Inhibition of neuronally mediated secretion in rat colonic mucosa by prostaglandin D2. Goerg, K.J., Wanitschke, R., Diener, M., Rummel, W. Gastroenterology (1992) [Pubmed]
  8. Changes in adrenergic and peptidergic nerves in the submucous plexus of streptozocin-diabetic rat ileum. Belai, A., Burnstock, G. Gastroenterology (1990) [Pubmed]
  9. Surfactants selectively ablate enteric neurons of the rat jejunum. Fox, D.A., Epstein, M.L., Bass, P. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
  10. Morphometric aspects of the submucous plexus in whole-mount preparations of normal human distal colon. Wester, T., O'Briain, S., Puri, P. J. Pediatr. Surg. (1998) [Pubmed]
  11. Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea-pig. Lomax, A.E., Mawe, G.M., Sharkey, K.A. J. Physiol. (Lond.) (2005) [Pubmed]
  12. Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. Neild, T.O., Shen, K.Z., Surprenant, A. J. Physiol. (Lond.) (1990) [Pubmed]
  13. Contractile responses to substance P and related peptides of the isolated muscularis mucosae of the guinea-pig oesophagus. Kamikawa, Y., Shimo, Y. Br. J. Pharmacol. (1984) [Pubmed]
  14. Localization of substance P binding sites in submucous plexus of guinea pig ileum, using whole-mount autoradiography. Burcher, E., Bornstein, J.C. Synapse (1988) [Pubmed]
  15. Serotonin receptors on submucous neurons in guinea pig colon. Frieling, T., Cooke, H.J., Wood, J.D. Am. J. Physiol. (1991) [Pubmed]
  16. Origins of peptide and norepinephrine nerves in the mucosa of the guinea pig small intestine. Keast, J.R., Furness, J.B., Costa, M. Gastroenterology (1984) [Pubmed]
  17. Mu and delta receptors belong to a family of receptors that are coupled to potassium channels. North, R.A., Williams, J.T., Surprenant, A., Christie, M.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  18. Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine. Hirst, G.D., Silinsky, E.M. J. Physiol. (Lond.) (1975) [Pubmed]
  19. Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. Kirchgessner, A.L., Tamir, H., Gershon, M.D. J. Neurosci. (1992) [Pubmed]
  20. Potassium channels opened by noradrenaline and other transmitters in excised membrane patches of guinea-pig submucosal neurones. Shen, K.Z., North, R.A., Surprenant, A. J. Physiol. (Lond.) (1992) [Pubmed]
  21. A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon. Spencer, N.J., Hennig, G.W., Smith, T.K. J. Physiol. (Lond.) (2002) [Pubmed]
  22. Inhibitory synaptic potentials recorded from mammalian neurones prolonged by blockade of noradrenaline uptake. Surprenant, A., Williams, J.T. J. Physiol. (Lond.) (1987) [Pubmed]
  23. Inhibitory synaptic potentials resulting from alpha 2-adrenoceptor activation in guinea-pig submucous plexus neurones. North, R.A., Surprenant, A. J. Physiol. (Lond.) (1985) [Pubmed]
  24. The co-localization of neuropeptides in the submucosa of the small intestine of normal Wistar and non-diabetic BB rats. Pataky, D.M., Curtis, S.B., Buchan, A.M. Neuroscience (1990) [Pubmed]
  25. Transient expression of NOS-II during development of the murine enteric nervous system. Arnhold, S., When, M., Labbé, D., Andressen, C., Addicks, K. J. Mol. Histol. (2004) [Pubmed]
  26. Distribution of adrenergic receptors in the enteric nervous system of the guinea pig, mouse, and rat. Nasser, Y., Ho, W., Sharkey, K.A. J. Comp. Neurol. (2006) [Pubmed]
  27. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Braak, H., de Vos, R.A., Bohl, J., Del Tredici, K. Neurosci. Lett. (2006) [Pubmed]
  28. Extrinsic control of the release of galanin and VIP from intrinsic nerves of isolated, perfused, porcine ileum. Messell, T., Harling, H., Poulsen, S.S., Bersani, M., Holst, J.J. Regul. Pept. (1992) [Pubmed]
  29. Localization of NADPH-diaphorase activity in the submucous plexus of the guinea-pig intestine: light and electron microscopic studies. Wang, X.Y., Wong, W.C., Ling, E.A. J. Neurocytol. (1995) [Pubmed]
WikiGenes - Universities