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Gene Review

CLEC4G  -  C-type lectin domain family 4, member G

Homo sapiens

Synonyms: C-type lectin domain family 4 member G, DTTR431, LP2698, LSECtin, UNQ431, ...
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Disease relevance of CLEC4G


High impact information on CLEC4G


Biological context of CLEC4G

  • Finally, we demonstrate that LSECtin is N-linked glycosylated and that glycosylation is required for cell surface expression [1].

Associations of CLEC4G with chemical compounds

  • Ligand binding to LSECtin was inhibited by EGTA but not by mannan, suggesting that LSECtin unlike DC-SIGN/R does not recognize high-mannose glycans on viral GPs [1].

Physical interactions of CLEC4G

  • LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus [1].

Other interactions of CLEC4G

  • In summary, we identified LSECtin as an attachment factor that in conjunction with DC-SIGNR might concentrate viral pathogens in liver and lymph nodes [1].


  1. LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. Gramberg, T., Hofmann, H., Möller, P., Lalor, P.F., Marzi, A., Geier, M., Krumbiegel, M., Winkler, T., Kirchhoff, F., Adams, D.H., Becker, S., Münch, J., Pöhlmann, S. Virology (2005) [Pubmed]
  2. Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. Liu, W., Tang, L., Zhang, G., Wei, H., Cui, Y., Guo, L., Gou, Z., Chen, X., Jiang, D., Zhu, Y., Kang, G., He, F. J. Biol. Chem. (2004) [Pubmed]
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