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Gene Review

CLEC4M  -  C-type lectin domain family 4, member M

Homo sapiens

Synonyms: C-type lectin domain family 4 member M, CD209 antigen-like protein 1, CD209L, CD209L1, CD299, ...
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Disease relevance of CLEC4M


High impact information on CLEC4M


Chemical compound and disease context of CLEC4M


Biological context of CLEC4M


Anatomical context of CLEC4M


Associations of CLEC4M with chemical compounds


Regulatory relationships of CLEC4M


Other interactions of CLEC4M


Analytical, diagnostic and therapeutic context of CLEC4M

  • We therefore explored the presence of DC-SIGNR in these compartments with a more sensitive limiting dilution RT-PCR, which also allowed for quantification of alternatively spliced mRNA isoforms [11].
  • Cross-linking, equilibrium ultracentrifugation, and circular dichroism studies of soluble recombinant fragments of DC-SIGN and DC-SIGNR have been used to show that the extracellular domain of each receptor is a tetramer stabilized by an alpha-helical stalk [13].
  • Digestion of purified soluble recombinant DC-SIGN and DC-SIGNR, followed by N-terminal sequencing and MALDI mass spectrometry, indicated in each case one major cleavage site and several minor sites, the former correlating well with Der p 1 enzymology and the folded state of the substrate proteins [17].
  • In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR [24].


  1. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Chan, V.S., Chan, K.Y., Chen, Y., Poon, L.L., Cheung, A.N., Zheng, B., Chan, K.H., Mak, W., Ngan, H.Y., Xu, X., Screaton, G., Tam, P.K., Austyn, J.M., Chan, L.C., Yip, S.P., Peiris, M., Khoo, U.S., Lin, C.L. Nat. Genet. (2006) [Pubmed]
  2. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. Bashirova, A.A., Geijtenbeek, T.B., van Duijnhoven, G.C., van Vliet, S.J., Eilering, J.B., Martin, M.P., Wu, L., Martin, T.D., Viebig, N., Knolle, P.A., KewalRamani, V.N., van Kooyk, Y., Carrington, M. J. Exp. Med. (2001) [Pubmed]
  3. L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. Cormier, E.G., Durso, R.J., Tsamis, F., Boussemart, L., Manix, C., Olson, W.C., Gardner, J.P., Dragic, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. Soilleux, E.J., Barten, R., Trowsdale, J. J. Immunol. (2000) [Pubmed]
  5. Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity. Soilleux, E.J., Morris, L.S., Rushbrook, S., Lee, B., Coleman, N. Hum. Pathol. (2002) [Pubmed]
  6. The Immunobiology of SARS (*). Chen, J., Subbarao, K. Annu. Rev. Immunol. (2007) [Pubmed]
  7. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. Tassaneetrithep, B., Burgess, T.H., Granelli-Piperno, A., Trumpfheller, C., Finke, J., Sun, W., Eller, M.A., Pattanapanyasat, K., Sarasombath, S., Birx, D.L., Steinman, R.M., Schlesinger, S., Marovich, M.A. J. Exp. Med. (2003) [Pubmed]
  8. The Location of Asparagine-linked Glycans on West Nile Virions Controls Their Interactions with CD209 (Dendritic Cell-specific ICAM-3 Grabbing Nonintegrin). Davis, C.W., Mattei, L.M., Nguyen, H.Y., Ansarah-Sobrinho, C., Doms, R.W., Pierson, T.C. J. Biol. Chem. (2006) [Pubmed]
  9. West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection. Davis, C.W., Nguyen, H.Y., Hanna, S.L., Sánchez, M.D., Doms, R.W., Pierson, T.C. J. Virol. (2006) [Pubmed]
  10. Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. Mummidi, S., Catano, G., Lam, L., Hoefle, A., Telles, V., Begum, K., Jimenez, F., Ahuja, S.S., Ahuja, S.K. J. Biol. Chem. (2001) [Pubmed]
  11. Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms. Liu, H., Hladik, F., Andrus, T., Sakchalathorn, P., Lentz, G.M., Fialkow, M.F., Corey, L., McElrath, M.J., Zhu, T. Eur. J. Hum. Genet. (2005) [Pubmed]
  12. Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Feinberg, H., Mitchell, D.A., Drickamer, K., Weis, W.I. Science (2001) [Pubmed]
  13. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. Mitchell, D.A., Fadden, A.J., Drickamer, K. J. Biol. Chem. (2001) [Pubmed]
  14. Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection. Halary, F., Amara, A., Lortat-Jacob, H., Messerle, M., Delaunay, T., Houlès, C., Fieschi, F., Arenzana-Seisdedos, F., Moreau, J.F., Déchanet-Merville, J. Immunity (2002) [Pubmed]
  15. L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus. Gardner, J.P., Durso, R.J., Arrigale, R.R., Donovan, G.P., Maddon, P.J., Dragic, T., Olson, W.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles. Lozach, P.Y., Amara, A., Bartosch, B., Virelizier, J.L., Arenzana-Seisdedos, F., Cosset, F.L., Altmeyer, R. J. Biol. Chem. (2004) [Pubmed]
  17. The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses. Furmonaviciene, R., Ghaemmaghami, A.M., Boyd, S.E., Jones, N.S., Bailey, K., Willis, A.C., Sewell, H.F., Mitchell, D.A., Shakib, F. Clin. Exp. Allergy (2007) [Pubmed]
  18. Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. Ludwig, I.S., Lekkerkerker, A.N., Depla, E., Bosman, F., Musters, R.J., Depraetere, S., van Kooyk, Y., Geijtenbeek, T.B. J. Virol. (2004) [Pubmed]
  19. Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. Liu, W., Tang, L., Zhang, G., Wei, H., Cui, Y., Guo, L., Gou, Z., Chen, X., Jiang, D., Zhu, Y., Kang, G., He, F. J. Biol. Chem. (2004) [Pubmed]
  20. Determination of DC-SIGN and DC-SIGNR repeat region variations. Liu, H., Zhu, T. Methods Mol. Biol. (2005) [Pubmed]
  21. Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN. Mukhtar, M., Harley, S., Chen, P., BouHamdan, M., Patel, C., Acheampong, E., Pomerantz, R.J. Virology (2002) [Pubmed]
  22. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Jeffers, S.A., Tusell, S.M., Gillim-Ross, L., Hemmila, E.M., Achenbach, J.E., Babcock, G.J., Thomas, W.D., Thackray, L.B., Young, M.D., Mason, R.J., Ambrosino, D.M., Wentworth, D.E., Demartini, J.C., Holmes, K.V. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  23. LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. Gramberg, T., Hofmann, H., Möller, P., Lalor, P.F., Marzi, A., Geier, M., Krumbiegel, M., Winkler, T., Kirchhoff, F., Adams, D.H., Becker, S., Münch, J., Pöhlmann, S. Virology (2005) [Pubmed]
  24. The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection. Nattermann, J., Ahlenstiel, G., Berg, T., Feldmann, G., Nischalke, H.D., Müller, T., Rockstroh, J., Woitas, R., Sauerbruch, T., Spengler, U. J. Viral Hepat. (2006) [Pubmed]
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