Gene Review:
CLEC4M - C-type lectin domain family 4, member M
Homo sapiens
Synonyms:
C-type lectin domain family 4 member M, CD209 antigen-like protein 1, CD209L, CD209L1, CD299, ...
- Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Chan, V.S., Chan, K.Y., Chen, Y., Poon, L.L., Cheung, A.N., Zheng, B., Chan, K.H., Mak, W., Ngan, H.Y., Xu, X., Screaton, G., Tam, P.K., Austyn, J.M., Chan, L.C., Yip, S.P., Peiris, M., Khoo, U.S., Lin, C.L. Nat. Genet. (2006)
- A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. Bashirova, A.A., Geijtenbeek, T.B., van Duijnhoven, G.C., van Vliet, S.J., Eilering, J.B., Martin, M.P., Wu, L., Martin, T.D., Viebig, N., Knolle, P.A., KewalRamani, V.N., van Kooyk, Y., Carrington, M. J. Exp. Med. (2001)
- L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. Cormier, E.G., Durso, R.J., Tsamis, F., Boussemart, L., Manix, C., Olson, W.C., Gardner, J.P., Dragic, T. Proc. Natl. Acad. Sci. U.S.A. (2004)
- DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. Soilleux, E.J., Barten, R., Trowsdale, J. J. Immunol. (2000)
- Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity. Soilleux, E.J., Morris, L.S., Rushbrook, S., Lee, B., Coleman, N. Hum. Pathol. (2002)
- The Immunobiology of SARS (*). Chen, J., Subbarao, K. Annu. Rev. Immunol. (2007)
- DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. Tassaneetrithep, B., Burgess, T.H., Granelli-Piperno, A., Trumpfheller, C., Finke, J., Sun, W., Eller, M.A., Pattanapanyasat, K., Sarasombath, S., Birx, D.L., Steinman, R.M., Schlesinger, S., Marovich, M.A. J. Exp. Med. (2003)
- The Location of Asparagine-linked Glycans on West Nile Virions Controls Their Interactions with CD209 (Dendritic Cell-specific ICAM-3 Grabbing Nonintegrin). Davis, C.W., Mattei, L.M., Nguyen, H.Y., Ansarah-Sobrinho, C., Doms, R.W., Pierson, T.C. J. Biol. Chem. (2006)
- West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection. Davis, C.W., Nguyen, H.Y., Hanna, S.L., Sánchez, M.D., Doms, R.W., Pierson, T.C. J. Virol. (2006)
- Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts. Mummidi, S., Catano, G., Lam, L., Hoefle, A., Telles, V., Begum, K., Jimenez, F., Ahuja, S.S., Ahuja, S.K. J. Biol. Chem. (2001)
- Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms. Liu, H., Hladik, F., Andrus, T., Sakchalathorn, P., Lentz, G.M., Fialkow, M.F., Corey, L., McElrath, M.J., Zhu, T. Eur. J. Hum. Genet. (2005)
- Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Feinberg, H., Mitchell, D.A., Drickamer, K., Weis, W.I. Science (2001)
- A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. Mitchell, D.A., Fadden, A.J., Drickamer, K. J. Biol. Chem. (2001)
- Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection. Halary, F., Amara, A., Lortat-Jacob, H., Messerle, M., Delaunay, T., Houlès, C., Fieschi, F., Arenzana-Seisdedos, F., Moreau, J.F., Déchanet-Merville, J. Immunity (2002)
- L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus. Gardner, J.P., Durso, R.J., Arrigale, R.R., Donovan, G.P., Maddon, P.J., Dragic, T., Olson, W.C. Proc. Natl. Acad. Sci. U.S.A. (2003)
- C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles. Lozach, P.Y., Amara, A., Bartosch, B., Virelizier, J.L., Arenzana-Seisdedos, F., Cosset, F.L., Altmeyer, R. J. Biol. Chem. (2004)
- The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses. Furmonaviciene, R., Ghaemmaghami, A.M., Boyd, S.E., Jones, N.S., Bailey, K., Willis, A.C., Sewell, H.F., Mitchell, D.A., Shakib, F. Clin. Exp. Allergy (2007)
- Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. Ludwig, I.S., Lekkerkerker, A.N., Depla, E., Bosman, F., Musters, R.J., Depraetere, S., van Kooyk, Y., Geijtenbeek, T.B. J. Virol. (2004)
- Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. Liu, W., Tang, L., Zhang, G., Wei, H., Cui, Y., Guo, L., Gou, Z., Chen, X., Jiang, D., Zhu, Y., Kang, G., He, F. J. Biol. Chem. (2004)
- Determination of DC-SIGN and DC-SIGNR repeat region variations. Liu, H., Zhu, T. Methods Mol. Biol. (2005)
- Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN. Mukhtar, M., Harley, S., Chen, P., BouHamdan, M., Patel, C., Acheampong, E., Pomerantz, R.J. Virology (2002)
- CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Jeffers, S.A., Tusell, S.M., Gillim-Ross, L., Hemmila, E.M., Achenbach, J.E., Babcock, G.J., Thomas, W.D., Thackray, L.B., Young, M.D., Mason, R.J., Ambrosino, D.M., Wentworth, D.E., Demartini, J.C., Holmes, K.V. Proc. Natl. Acad. Sci. U.S.A. (2004)
- LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus. Gramberg, T., Hofmann, H., Möller, P., Lalor, P.F., Marzi, A., Geier, M., Krumbiegel, M., Winkler, T., Kirchhoff, F., Adams, D.H., Becker, S., Münch, J., Pöhlmann, S. Virology (2005)
- The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection. Nattermann, J., Ahlenstiel, G., Berg, T., Feldmann, G., Nischalke, H.D., Müller, T., Rockstroh, J., Woitas, R., Sauerbruch, T., Spengler, U. J. Viral Hepat. (2006)