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Gene Review

nrv1  -  nervana 1

Drosophila melanogaster

Synonyms: 42kDa, CG9258, Dmel\CG9258, K-ATPase, NKA-alpha, ...
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High impact information on nrv1


Biological context of nrv1

  • P-element transformation vectors were constructed, which contained either 7.7kb of Nrv2 or 3.5kb Nrv1 5' flanking DNA driving expression of a lacZ reporter gene [4].
  • Taken together these results demonstrate that the cardiac glycoside binding site of the alpha isoforms of the Na,K-ATPase have a physiological function and supports the hypothesis for a role of the endogenous cardiac glycosides [1].
  • Using the Gal4-UAS system we have limited expression of alpha transgenes to cell types that normally express a particular Drosophila Na(+),K(+)-ATPase beta (Nervana) subunit isoform (Nrv1 or 2) [5].

Analytical, diagnostic and therapeutic context of nrv1

  • Three cDNA clones (designated Nrv1, Nrv2.1, and Nrv2.2) were isolated that code for proteins recognized by anti-Nrv mAbs on Western blots [2].


  1. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Dostanic-Larson, I., Van Huysse, J.W., Lorenz, J.N., Lingrel, J.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Two Drosophila nervous system antigens, Nervana 1 and 2, are homologous to the beta subunit of Na+,K(+)-ATPase. Sun, B., Salvaterra, P.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control. Paul, S.M., Palladino, M.J., Beitel, G.J. Development (2007) [Pubmed]
  4. Organization and transcriptional regulation of Drosophila Na(+), K(+)-ATPase beta subunit genes: Nrv1 and Nrv2. Xu, P., Sun, B., Salvaterra, P.M. Gene (1999) [Pubmed]
  5. In vivo modification of Na(+),K(+)-ATPase activity in Drosophila. Sun, B., Xu, P., Wang, W., Salvaterra, P.M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2001) [Pubmed]
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