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Gene Review

SA  -  Stromalin

Drosophila melanogaster

Synonyms: CG3423, DSA, DSA1, DmSA, Dmel\CG3423, ...
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Disease relevance of SA

  • The DSA protein has been cloned and expressed in a baculovirus system, and polyclonal antibodies were generated against the recombinant molecule [1].

High impact information on SA

  • Drosophila nipped-B protein supports sister chromatid cohesion and opposes the stromalin/Scc3 cohesion factor to facilitate long-range activation of the cut gene [2].
  • Serial transovarial passage of SA virus in Ae. albopictus did not alter its plaque morphology, infectivity for mosquitoes, or pathogenicity for vertebrates [3].
  • The behavior of SA virus in Ae. albopictus was similar to that of sigma virus in Drosophila melanogaster, suggesting that some females in the transovarial transmission-efficient line had developed a chronic infection of their germinal cells (oogonia) [3].
  • This cDNA fragment was used as a radiolabeled probe for screening a cDNA library from Drosophila embryos, and we have cloned a full-length cDNA for the SA homolog from an insect [1].
  • The in situ hybridization experiments indicate that the DSA messenger is expressed mainly in neurogenic territories in the embryonic development of Drosophila [1].

Analytical, diagnostic and therapeutic context of SA


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