High impact information on Oogonia

• We suggest that eEF-1 alpha S pseudogenes are generated in primordial germ cells of the embryo before they differentiate into oogonia or spermatogonia [1].
• Following brief incorporation of tritiated uridine, nucleolar labelling is active in oogonia [2].
• The betaA subunit was expressed by oogonia, and the betaB subunit and activin receptors were expressed by both oogonia and somatic cells [3].
• In this report, we investigated the effects of SCF and LIF, alone and in combination, on the survival of oogonia and oocytes, and elaborated on components of the signal transduction pathway used by these molecules, after validating a method of culturing fetal mouse ovaries [4].
• In the ovary, Vasa is the highest in oogonia but persists throughout oogenesis [5].

Biological context of Oogonia

• In day 90 and 100 fetal ovaries, mRNA encoding c-kit was not detected in association with oogonia during the period of meiosis (to prophase I) but was present in some of the isolated oocytes [6].

Anatomical context of Oogonia

• The most remarkable feature of oogonia is that they have typical juxtanuclear centrioles (diplosomes) with dense pericentriolar material, which nucleate microtubules, characteristic of functional centrosomes organizing the cytoskeleton [7].
• Bone marrow tissue oogonia were PAS and PAS-D positive, identical to fungal ones [8].
• An autoradiographic study of the effects of mammalian gonadotropins (follicle-stimulating hormone and luteinizing hormone) and estradiol-17beta on [3H]thymidine labeling of surface epithelial cells, prefollicular cells, and oogonia in the ovary of the lizard Anolis carolinensis [9].

Associations of Oogonia with chemical compounds

• Treatment of ovary fragments with activin A in vitro increased both the number of oogonia present and oogonial proliferation, as detected by bromodeoxyuridine (BrdU) incorporation [3].
• A single meal of cis-diamminedichloroplatinum (DDP) fed to virgin braconid wasps decreased drastically the number of eggs derived from oogonia [10].
• Quantitative histological analysis revealed in atrazine-exposed ovaries a significant (p < 0.05) increase in frequency of secondary oogonia [11].
• However, the female commitment of the Bidder's organ occurs independently from steroid treatments that lead to an acceleration or slackening of the processes of proliferation and differentiation of oogonia [12].
• The germination of zoospores and growth of germlings were so severely affected that induction of oogonia remained completely inhibited at 1 mg/l HgCl2 [13].

Gene context of Oogonia

• While mitotic PGCs of either sex are shown to bind radiolabeled bFGF, oogonia that are undergoing meiotic arrest exhibit reduced bFGF binding, indicating potential developmental regulation of an FGF receptor [14].
• As detected by either alkaline phosphatase or GCNA1, we did not detect long-term survival of either prospermatogonia or oogonia under conditions that support the survival, proliferation, and differentiation of earlier premigratory cells [15].
• The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia [16].
• It is possible that thymic peptides regulate the release of GnRH-LH in utero in women and are important in determining the rate at which primordial follicles and oogonia are lost [17].
• Finally, a c-kit homolog is expressed in gonadal oogonia and growing oocytes as in mice but is also not found in PGCs [18].

Analytical, diagnostic and therapeutic context of Oogonia

• Similarly, the mitotic index in oogonia was increased 24 h after receiving a pulse of FSH; this result was confirmed by an increase in the number of germ cells that incorporated bromodeoxyuridine (BrdU) [19].

References