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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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High impact information on Oogonia


Biological context of Oogonia

  • In day 90 and 100 fetal ovaries, mRNA encoding c-kit was not detected in association with oogonia during the period of meiosis (to prophase I) but was present in some of the isolated oocytes [6].

Anatomical context of Oogonia


Associations of Oogonia with chemical compounds

  • Treatment of ovary fragments with activin A in vitro increased both the number of oogonia present and oogonial proliferation, as detected by bromodeoxyuridine (BrdU) incorporation [3].
  • A single meal of cis-diamminedichloroplatinum (DDP) fed to virgin braconid wasps decreased drastically the number of eggs derived from oogonia [10].
  • Quantitative histological analysis revealed in atrazine-exposed ovaries a significant (p < 0.05) increase in frequency of secondary oogonia [11].
  • However, the female commitment of the Bidder's organ occurs independently from steroid treatments that lead to an acceleration or slackening of the processes of proliferation and differentiation of oogonia [12].
  • The germination of zoospores and growth of germlings were so severely affected that induction of oogonia remained completely inhibited at 1 mg/l HgCl2 [13].

Gene context of Oogonia

  • While mitotic PGCs of either sex are shown to bind radiolabeled bFGF, oogonia that are undergoing meiotic arrest exhibit reduced bFGF binding, indicating potential developmental regulation of an FGF receptor [14].
  • As detected by either alkaline phosphatase or GCNA1, we did not detect long-term survival of either prospermatogonia or oogonia under conditions that support the survival, proliferation, and differentiation of earlier premigratory cells [15].
  • The data appear to indicate that the FMR1 gene may play a role in the development and proliferation of oogonia [16].
  • It is possible that thymic peptides regulate the release of GnRH-LH in utero in women and are important in determining the rate at which primordial follicles and oogonia are lost [17].
  • Finally, a c-kit homolog is expressed in gonadal oogonia and growing oocytes as in mice but is also not found in PGCs [18].

Analytical, diagnostic and therapeutic context of Oogonia


  1. Germ cell-specific expression of a gene encoding eukaryotic translation elongation factor 1 alpha (eEF-1 alpha) and generation of eEF-1 alpha retropseudogenes in Xenopus laevis. Abdallah, B., Hourdry, J., Krieg, P.A., Denis, H., Mazabraud, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Ultrastructure and activity of the nucleolar organizer in the mouse oocyte during meiotic prophase. Mirre, C., Stahl, A. J. Cell. Sci. (1978) [Pubmed]
  3. Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation. Martins da Silva, S.J., Bayne, R.A., Cambray, N., Hartley, P.S., McNeilly, A.S., Anderson, R.A. Dev. Biol. (2004) [Pubmed]
  4. Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse. Morita, Y., Manganaro, T.F., Tao, X.J., Martimbeau, S., Donahoe, P.K., Tilly, J.L. Endocrinology (1999) [Pubmed]
  5. Differential expression of vasa RNA and protein during spermatogenesis and oogenesis in the gibel carp (Carassius auratus gibelio), a bisexually and gynogenetically reproducing vertebrate. Xu, H., Gui, J., Hong, Y. Dev. Dyn. (2005) [Pubmed]
  6. Localization of mRNA encoding c-kit during the initiation of folliculogenesis in ovine fetal ovaries. Clark, D.E., Tisdall, D.J., Fidler, A.E., McNatty, K.P. J. Reprod. Fertil. (1996) [Pubmed]
  7. Fine structure of human oogonia in the foetal ovary. Sathananthan, A.H., Selvaraj, K., Trounson, A. Mol. Cell. Endocrinol. (2000) [Pubmed]
  8. Description of primordial germ cells, oogonia, oocytes and embryo-like growth in squash preparations of tissues from hematological malignancies. Logothetou-Rella, H. Histol. Histopathol. (1996) [Pubmed]
  9. An autoradiographic study of the effects of mammalian gonadotropins (follicle-stimulating hormone and luteinizing hormone) and estradiol-17beta on [3H]thymidine labeling of surface epithelial cells, prefollicular cells, and oogonia in the ovary of the lizard Anolis carolinensis. Tokarz, R.R. Gen. Comp. Endocrinol. (1978) [Pubmed]
  10. The pattern of damage to the oogenetic series of cells after a single feeding of cis-diamminedichloroplatinum to Habrobracon females. Grosch, D.S., Segreti, W.O. Mutat. Res. (1983) [Pubmed]
  11. Response of the amphibian tadpole Xenopus laevis to atrazine during sexual differentiation of the ovary. Tavera-Mendoza, L., Ruby, S., Brousseau, P., Fournier, M., Cyr, D., Marcogliese, D. Environ. Toxicol. Chem. (2002) [Pubmed]
  12. The effects of aromatase and 5 alpha-reductase inhibitors, antiandrogen, and sex steroids on Bidder's organs development and gonadal differentiation in Bufo bufo tadpoles. Petrini, S., Zaccanti, F. J. Exp. Zool. (1998) [Pubmed]
  13. Toxic effects of HgCl2 on the growth and oogonium formation in Oedogonium hatei. Singh, H.V. Microbios (2001) [Pubmed]
  14. Role of fibroblast growth factors and their receptors in mouse primordial germ cell growth. Resnick, J.L., Ortiz, M., Keller, J.R., Donovan, P.J. Biol. Reprod. (1998) [Pubmed]
  15. Differentiation of murine premigratory primordial germ cells in culture. Richards, A.J., Enders, G.C., Resnick, J.L. Biol. Reprod. (1999) [Pubmed]
  16. Obstetrical and gynecological complications in fragile X carriers: a multicenter study. Schwartz, C.E., Dean, J., Howard-Peebles, P.N., Bugge, M., Mikkelsen, M., Tommerup, N., Hull, C., Hagerman, R., Holden, J.J., Stevenson, R.E. Am. J. Med. Genet. (1994) [Pubmed]
  17. The thymus gland and reproduction: do thymic peptides influence the reproductive lifespan in females? Rebar, R.W. Journal of the American Geriatrics Society. (1982) [Pubmed]
  18. Gene expression in the axolotl germ line: Axdazl, Axvh, Axoct-4, and Axkit. Bachvarova, R.F., Masi, T., Drum, M., Parker, N., Mason, K., Patient, R., Johnson, A.D. Dev. Dyn. (2004) [Pubmed]
  19. Follicle-stimulating hormone increases cell proliferation in the ovary and the testis of the chick embryo. Méndez, M.C., Ramírez, M., Varela, A.R., Chávez, B., Pedernera, E. Gen. Comp. Endocrinol. (2003) [Pubmed]
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