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Gene Review

STAG1  -  stromal antigen 1

Homo sapiens

Synonyms: Cohesin subunit SA-1, SA-1, SA1, SCC3 homolog 1, SCC3A, ...
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Disease relevance of STAG1


High impact information on STAG1


Biological context of STAG1


Anatomical context of STAG1

  • Human CD4-positive T cells were cultured with phytohemagglutinin in the presence or absence of 0.1 microM recombinant cystatin SA1 or SA2 [11].
  • Recent work has implicated the System N transporter SN1 in the efflux of glutamine from astrocytes and the very closely related System A transporters SA1 and SA2 in glutamine uptake by neurons [12].
  • Setting optimal parameters for in vitro electrotransfection of B16F1, SA1, LPB, SCK, L929 and CHO cells using predefined exponentially decaying electric pulses [13].
  • 1. Multiple linear regression was performed in 56 subjects with dependent variable SA at 4 months after starting PD (SA2), and independent variables: age, sex, diabetes, 4h-D/Pcr, predialysis SA (SA1), nPCR, PD-duration, modality, Kt/V, Ccr, and daily volume excreted normalized to body water (Vt/V) [14].

Associations of STAG1 with chemical compounds

  • A continuing study of the ingredients of Puerariae Radix, the roots of Pueraria lobata (WILLD.) OHWI, which is one of the most important crude drugs, has resulted in the first isolation of four new oleanene-type triterpene glycosides, named kudzusaponins SA1, SA2, SA3 and C1 (1-4) [15].
  • Here, we describe a very simple, reliable, sensitive standard-addition method for the simultaneous determination of S1P, sphingosine (SPH), sphinganine (SAPH) and sphinganine-1-phosphate (SA1P) in human and rat plasma samples [16].

Other interactions of STAG1

  • Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway [7].
  • Two proteins, SA1 and SA2, are given by two alleles of CST2, viz., CST2*1 and CST*2 [17].
  • The difference in the electrophoretic positions of the two proteins, SA1 and SA2, in a basic gel and in an isoelectric focusing gel agreed with the expected mobilities of the proteins with the SA2 variant at a more anodal position [18].
  • Recombinant cystatin SA1 did not inhibit human cathepsin H but SA2 inhibited it slightly (Ki = 528 nM) [19].
  • An avidin-biotin-peroxidase labelling method was applied to frozen sections and to routine-fixed, paraffin-embedded sections, and compared with immunohistochemical results of stromal antigen detection (type IV collagen, laminin and fibronectin) obtained in parallel on different neoplasias [20].

Analytical, diagnostic and therapeutic context of STAG1


  1. Prostate - specific G protein couple receptor genes and stag1/pmepa1 in peripheral blood from patients with prostatic cancer. Cardillo, M.R., Di Silverio, F. International journal of immunopathology and pharmacology (2006) [Pubmed]
  2. Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. Rae, F.K., Hooper, J.D., Nicol, D.L., Clements, J.A. Mol. Carcinog. (2001) [Pubmed]
  3. Association of 16/6 and SA1 anti-DNA idiotypes with anticardiolipin antibodies and clinical manifestations in a large cohort of SLE patients. European Concerted Action on the Immunogenetics of SLE. Galeazzi, M., Bellisai, F., Sebastiani, G.D., Morozzi, G., Marcolongo, R., Houssiau, F., Cervera, R., Levy, Y., George, J., Sherer, Y., Shoenfeld, Y. Clinical and experimental rheumatology. (1998) [Pubmed]
  4. Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer. Hofheinz, R.D., al-Batran, S.E., Hartmann, F., Hartung, G., Jäger, D., Renner, C., Tanswell, P., Kunz, U., Amelsberg, A., Kuthan, H., Stehle, G. Onkologie. (2003) [Pubmed]
  5. Does serum albumin at start of continuous ambulatory peritoneal dialysis (CAPD) or its drop during CAPD determine patient outcome? Sharma, A.P., Gupta, A., Sharma, R.K., Agarwal, D.K., Sural, S., Wardhe, D.J. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. (2000) [Pubmed]
  6. Isolation of the progenitor cells of the sympathoadrenal lineage from embryonic sympathetic ganglia with the SA monoclonal antibodies. Carnahan, J.F., Patterson, P.H. J. Neurosci. (1991) [Pubmed]
  7. Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. Anazawa, Y., Arakawa, H., Nakagawa, H., Nakamura, Y. Oncogene (2004) [Pubmed]
  8. Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. Fassnacht, M., Lee, J., Milazzo, C., Boczkowski, D., Su, Z., Nair, S., Gilboa, E. Clin. Cancer Res. (2005) [Pubmed]
  9. Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. McGuinness, B.E., Hirota, T., Kudo, N.R., Peters, J.M., Nasmyth, K. PLoS Biol. (2005) [Pubmed]
  10. Autoimmunity to a cornea-associated stromal antigen in patients with Mooren's ulcer. Gottsch, J.D., Liu, S.H., Minkovitz, J.B., Goodman, D.F., Srinivasan, M., Stark, W.J. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  11. Cystatin SA, a cysteine proteinase inhibitor, induces interferon-gamma expression in CD4-positive T cells. Kato, T., Ito, T., Imatani, T., Minaguchi, K., Saitoh, E., Okuda, K. Biol. Chem. (2004) [Pubmed]
  12. Glutamine uptake by neurons: interaction of protons with system a transporters. Chaudhry, F.A., Schmitz, D., Reimer, R.J., Larsson, P., Gray, A.T., Nicoll, R., Kavanaugh, M., Edwards, R.H. J. Neurosci. (2002) [Pubmed]
  13. Setting optimal parameters for in vitro electrotransfection of B16F1, SA1, LPB, SCK, L929 and CHO cells using predefined exponentially decaying electric pulses. Cegovnik, U., Novaković, S. Bioelectrochemistry (Amsterdam, Netherlands) (2004) [Pubmed]
  14. The influence of total, dialysis, and residual renal urea clearances on serum albumin in peritoneal dialysis. Chow, N., Iliescu, E.A., Morton, A.R., Hartman, D., Hopman, W. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. (1998) [Pubmed]
  15. Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination. Arao, T., Kinjo, J., Nohara, T., Isobe, R. Chem. Pharm. Bull. (1995) [Pubmed]
  16. LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. Schmidt, H., Schmidt, R., Geisslinger, G. Prostaglandins Other Lipid Mediat. (2006) [Pubmed]
  17. Genetic polymorphisms of the CST2 locus coding for cystatin SA. Shintani, M., Minaguchi, K., Isemura, S., Saitoh, E., Sanada, K., Semba, T. Hum. Genet. (1994) [Pubmed]
  18. Sequence variations of the CST2 gene related to the polymorphism of salivary cystatin SA. Haga, T., Minaguchi, K. J. Dent. Res. (1999) [Pubmed]
  19. Production and characterization of two variants of human cystatin SA encoded by two alleles at the CST2 locus of the type 2 cystatin gene family. Saitoh, E., Minaguchi, K., Ishibashi, O. Arch. Biochem. Biophys. (1998) [Pubmed]
  20. Detection of extracellular matrix antigens (fibronectin, laminin, type IV in collagen) in paraffin embedded sections by avidin-biotin-peroxidase complex labelling. D'Errico, A., Biagini, G., Garbisa, S., Milani, M., Rizzoli, R., Vasi, V., Villanacci, V., Grigioni, W.F., Mancini, A.M. Basic and applied histochemistry. (1986) [Pubmed]
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