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Gene Review

TREML1  -  triggering receptor expressed on myeloid...

Homo sapiens

Synonyms: GLTL1825, PRO3438, TLT-1, TLT1, Trem-like transcript 1 protein, ...
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High impact information on TREML1

  • TLT-1 transcripts are abundant in bone marrow cells, but not in lymphocytes, and phosphorylated TLT-1 associates with SHP-1, suggesting that it is indeed an inhibitory receptor [1].
  • Here we characterize TLT-1 (TREM-like transcript-1), a putative inhibitory receptor within the TREM cluster that contains an extracellular V-set Ig domain, a proline-rich region, and an immune receptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail [1].
  • Triggering receptor expressed on myeloid cells like transcript-1 (TLT-1) is an abundant platelet-specific, type I transmembrane receptor [2].
  • The extracellular fragment of TLT-1 consists of a single, immunoglobulin-like domain connected to the platelet cell membrane by a linker region called the stalk [2].
  • In contrast to previously characterized ITIM receptors, TLT1 enhanced, rather than inhibited, FcepsilonRI-mediated calcium signaling in rat basophilic leukemia cells, a property dependent on the SHP-2 recruiting classical Y281 ITIM [3].

Anatomical context of TREML1

  • We report a novel triggering receptor expressed on myeloid cells (TREM) family member, TREM-like transcript-1 (TLT1), which differs from the activating members because its cytoplasmic tail contains two ITIMs at Y245 and Y281 [3].
  • Therefore, TLT1 represents a new costimulatory ITIM immunoreceptor and is the second ITIM-bearing receptor to be identified in platelets after platelet endothelial cell adhesion molecule-1 [3].

Analytical, diagnostic and therapeutic context of TREML1


  1. Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. Washington, A.V., Quigley, L., McVicar, D.W. Blood (2002) [Pubmed]
  2. The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment. Gattis, J.L., Washington, A.V., Chisholm, M.M., Quigley, L., Szyk, A., McVicar, D.W., Lubkowski, J. J. Biol. Chem. (2006) [Pubmed]
  3. Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. Barrow, A.D., Astoul, E., Floto, A., Brooke, G., Relou, I.A., Jennings, N.S., Smith, K.G., Ouwehand, W., Farndale, R.W., Alexander, D.R., Trowsdale, J. J. Immunol. (2004) [Pubmed]
  4. Preparation and characterization of monoclonal antibody against protein TREM-like transcript-1 (TLT-1). Lu, Y.T., Yen, C.Y., Ho, H.C., Chen, C.J., Wu, M.F., Hsieh, S.L. Hybridoma (2005) (2006) [Pubmed]
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