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Gene Review

OR6C2  -  olfactory receptor, family 6, subfamily C,...

Homo sapiens

Synonyms: HSA3, OR6C67, Olfactory receptor 6C2
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High impact information on OR6C2

  • UMPs are significant because they make genetic information cumulative among well-studied species and because they transfer such information from "map rich" organisms to those that are "map poor." As a demonstration of the utility of UMPs, comparative maps between human chromosome 3 (HSA3) and the rat genome have been constructed [1].
  • HSA3 is defined by at least 12 syntenic clusters located on seven different rat chromosomes [1].
  • These data, together with previous comparative mapping information between human, mouse, and bovine genomes, allow us to propose a distinct evolutionary pathway that connects HSA3 with the chromosomes of rodents, artiodactyls, and primates [1].
  • Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21 [2].
  • The syntenic arrangement of other HSA 3 homologs in the bovine was investigated by physically mapping five genes through segregation analysis of a bovine-hamster hybrid somatic cell panel [2].

Biological context of OR6C2


Analytical, diagnostic and therapeutic context of OR6C2


  1. Universal mapping probes and the origin of human chromosome 3. Hino, O., Testa, J.R., Buetow, K.H., Taguchi, T., Zhou, J.Y., Bremer, M., Bruzel, A., Yeung, R., Levan, G., Levan, K.K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21. Threadgill, D.S., Womack, J.E. Genomics (1991) [Pubmed]
  3. Sex, strain, and species differences affect recombination across an evolutionarily conserved segment of mouse chromosome 16. Reeves, R.H., Crowley, M.R., O'Hara, B.F., Gearhart, J.D. Genomics (1990) [Pubmed]
  4. Parallel RH mapping of BTA1 with HSA3 and HSA21. Rexroad, C.E., Womack, J.E. Mamm. Genome (1999) [Pubmed]
  5. Origin of human chromosome 21 and its consequences: a 50-million-year-old story. Richard, F., Dutrillaux, B. Chromosome Res. (1998) [Pubmed]
  6. Human chromosome 3 and pig chromosome 13 show complete synteny conservation but extensive gene-order differences. Sun, H.F., Ernst, C.W., Yerle, M., Pinton, P., Rothschild, M.F., Chardon, P., Rogel-Gaillard, C., Tuggle, C.K. Cytogenet. Cell Genet. (1999) [Pubmed]
  7. Human chromosome 3: high-resolution fluorescence in situ hybridization mapping of 40 unique NotI linking clones homologous to genes and cDNAs. Protopopov, A.I., Gizatullin, R.Z., Vorobieva, N.V., Protopopova, M.V., Kiss, C., Kashuba, V.I., Klein, G., Kisselev, L.L., Graphodatsky, A.S., Zabarovsky, E.R. Chromosome Res. (1996) [Pubmed]
  8. Linkage and comparative mapping of the locus controlling susceptibility towards E. COLI F4ab/ac diarrhoea in pigs. Jørgensen, C.B., Cirera, S., Anderson, S.I., Archibald, A.L., Raudsepp, T., Chowdhary, B., Edfors-Lilja, I., Andersson, L., Fredholm, M. Cytogenet. Genome Res. (2003) [Pubmed]
  9. Comparative mapping of human claudin-1 (CLDN1) in great apes. Nanda, I., Krämer, F., Weber, B.H., Schempp, W., Schmid, M. Cytogenet. Genome Res. (2005) [Pubmed]
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