The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

IFIT2  -  interferon-induced protein with...

Homo sapiens

Synonyms: CIG-42, G10P2, GARG-39, IFI-54, IFI-54K, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on IFIT2

  • Database search has revealed a high-level homology between RIG-G and several IFN-stimulated genes in human (ISG54K, ISG56K, and IFN-inducible and retinoic acid-inducible 58K gene) and some other species, defining a well conserved gene family [1].
  • IFI-56K and IFI-54K are two human genes that are strongly induced by interferon and viruses [2].
  • The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines [3].
  • Transfection of ISG-54 K promoter constructs, in which ISRE-I was replaced by ISRE-II, which generates a promoter with two ISRE-II segments, and vice versa (two ISRE-I), provided further evidence for a role of both elements in IFN-alpha induction [4].
  • The interferon-alpha(IFN-alpha)-regulated hamster ISG-54 K gene, which is activated in hamster CHO-12 cells at least 40-fold, was isolated and the promoter region was characterized in detail [4].
 

Biological context of IFIT2

 

Anatomical context of IFIT2

  • Treatment of various cell lines with poly(rI).poly(rC) leads to a clear accumulation of the IFI-54K mRNA to a level which sometimes even exceeds that obtained with high doses of interferon [5].
  • The (mutated) ISG-54 K promoter was linked to the CAT reporter gene and transiently expressed in CHO cells in the absence and presence of murine (Mu)IFN-alpha 6 [4].
  • Cultured cells treated with 12-O-tetradecanoylphorbol 13-acetate (TPA) for 72 h are desensitized to phorbol esters such that further addition of phorbols does not inhibit IFN-induced ISG-54K expression [7].
 

Associations of IFIT2 with chemical compounds

  • Among them, three IFN-related genes, an IFN receptor gene (IFNAR2) and two IFN-stimulated genes (ISG15K, ISG-54K), that were up-regulated following addition of 5-FU, were investigated [8].
 

Other interactions of IFIT2

  • We also showed that the IFI-54K and IFI-56K genes, unlike most of the IFN-inducible genes, are syntenic [9].
  • We have isolated by differential screening two cDNA clones corresponding to human genes inducible by IFN-alpha, termed IFI-4 and IFI-54K [9].
 

Analytical, diagnostic and therapeutic context of IFIT2

References

  1. Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes. Yu, M., Tong, J.H., Mao, M., Kan, L.X., Liu, M.M., Sun, Y.W., Fu, G., Jing, Y.K., Yu, L., Lepaslier, D., Lanotte, M., Wang, Z.Y., Chen, Z., Waxman, S., Wang, Y.X., Tan, J.Z., Chen, S.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24. Lafage, M., Clauss, I., Couez, D., Simonetti, J., Wathelet, M.G., Huez, G. Genomics (1992) [Pubmed]
  3. The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family. Wathelet, M.G., Clauss, I.M., Content, J., Huez, G.A. FEBS Lett. (1988) [Pubmed]
  4. The interferon-stimulated gene 54 K promoter contains two adjacent functional interferon-stimulated response elements of different strength, which act synergistically for maximal interferon-alpha inducibility. Bluyssen, H.A., Vlietstra, R.J., van der Made, A., Trapman, J. Eur. J. Biochem. (1994) [Pubmed]
  5. Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses. Wathelet, M.G., Clauss, I.M., Content, J., Huez, G.A. Eur. J. Biochem. (1988) [Pubmed]
  6. Transcriptional activation of CYP2C, MxA and Fas in sudden infant death syndrome. Beurton, F., Gueret, G., Horisberger, M., Cheron, G., Cresteil, T. Int. J. Mol. Med. (1999) [Pubmed]
  7. Characterization of two independent mechanisms by which interferon-induced gene expression is down regulated. Akai, H., Larner, A.C. Cell Regul. (1990) [Pubmed]
  8. 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Matsumura, Y., Yashiro, M., Ohira, M., Tabuchi, H., Hirakawa, K. Anticancer Res. (2005) [Pubmed]
  9. Cloning and chromosomal location of human genes inducible by type I interferon. Wathelet, M.G., Szpirer, J., Nols, C.B., Clauss, I.M., De Wit, L., Islam, M.Q., Levan, G., Horisberger, M.A., Content, J., Szpirer, C. Somat. Cell Mol. Genet. (1988) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities