The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

QRFP  -  pyroglutamylated RFamide peptide

Homo sapiens

Synonyms: 26RFa, Orexigenic neuropeptide QRFP, P518
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on P518

  • A dose-dependent stimulation of locomotor activity was observed after i.c.v. administration of 26RFa, 43RFa and 26RFa(1-16), but not 26RFa(20-26), 26RFa(8-16) or 9RFa [1].
  • As for several other RFamide peptides, 26RFa-containing neurons are present in the hypothalamus, notably in two nuclei involved in the control of feeding behavior [2].

High impact information on P518


Biological context of P518

  • Intracerebroventricular injection of 26RFa provokes a robust increase in food intake in rodents [5].
  • The strong conservation, from amphibians to mammals, of the amino acid sequence corresponding to the amphipathic helix and to the C-terminal flexible octapeptide of 26RFa, suggests that these two domains are crucial for the interaction of the peptide with its receptor [5].

Anatomical context of P518


Associations of P518 with chemical compounds

  • In methanol, 26RFa adopts a well-defined conformation consisting of an amphipathic alpha-helical structure (Pro4-Arg17), flanked by two N- and C-terminal disordered regions [5].

Other interactions of P518

  • A novel hypothalamic neuropeptide of the RFamide family, comprising 26 amino acids residues and thus termed 26RFa, has been recently characterized in human, and was found to be the endogenous ligand for the orphan G protein-coupled receptor GPR103 [5].


  1. Behavioral effects of 26RFamide and related peptides. do Rego, J.C., Leprince, J., Chartrel, N., Vaudry, H., Costentin, J. Peptides (2006) [Pubmed]
  2. Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates. Chartrel, N., Bruzzone, F., Leprince, J., Tollemer, H., Anouar, Y., Do-Régo, J.C., Ségalas-Milazzo, I., Guilhaudis, L., Cosette, P., Jouenne, T., Simonnet, G., Vallarino, M., Beauvillain, J.C., Costentin, J., Vaudry, H. Peptides (2006) [Pubmed]
  3. A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S.C., Iguchi, H., Kawasawa, Y.I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R.X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M., Sakai, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. Bruzzone, F., Lectez, B., Tollemer, H., Leprince, J., Dujardin, C., Rachidi, W., Chatenet, D., Baroncini, M., Beauvillain, J.C., Vallarino, M., Vaudry, H., Chartrel, N. J. Neurochem. (2006) [Pubmed]
  5. Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. Thuau, R., Guilhaudis, L., Ségalas-Milazzo, I., Chartrel, N., Oulyadi, H., Boivin, S., Fournier, A., Leprince, J., Davoust, D., Vaudry, H. Peptides (2005) [Pubmed]
  6. Discovery of novel regulatory peptides by reverse pharmacology: spotlight on chemerin and the RF-amide peptides metastin and QRFP. Kutzleb, C., Busmann, A., Wendland, M., Maronde, E. Curr. Protein Pept. Sci. (2005) [Pubmed]
WikiGenes - Universities