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TP04_0051  -  polymorphic immunodominant molecule

Theileria parva strain Muguga

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Disease relevance of TP04_0051

  • Finally, we showed that polyclonal rat Abs against recombinant PIM neutralize sporozoite infectivity in vitro, suggesting that the PIM Ag should be evaluated for its capacity to immunize cattle against East Coast Fever [1].

High impact information on TP04_0051


Biological context of TP04_0051


Anatomical context of TP04_0051


Analytical, diagnostic and therapeutic context of TP04_0051


  1. Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva. Toye, P.G., Metzelaar, M.J., Wijngaard, P.L., Nene, V., Iams, K., Roose, J., Nyanjui, J.K., Gobright, E., Musoke, A.J., Clevers, H.C. J. Immunol. (1995) [Pubmed]
  2. Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM. Casanova, C.L., Xue, G., Taracha, E.L., Dobbelaere, D.A. Mol. Biochem. Parasitol. (2006) [Pubmed]
  3. An unusual mosaic structure of the PIM gene of Theileria parva and its relationship to allelic diversity. Geysen, D., Bazarusanga, T., Brandt, J., Dolan, T.T. Mol. Biochem. Parasitol. (2004) [Pubmed]
  4. Characterization of a polymorphic Theileria annulata surface protein (TaSP) closely related to PIM of Theileria parva: implications for use in diagnostic tests and subunit vaccines. Schnittger, L., Katzer, F., Biermann, R., Shayan, P., Boguslawski, K., McKellar, S., Beyer, D., Shiels, B.R., Ahmed, J.S. Mol. Biochem. Parasitol. (2002) [Pubmed]
  5. Immunohistochemical detection of parasite antigens in Theileria parva-infected bovine lymphocytes. Honda, Y., Matsubara, Y., Morzaria, S., McKeever, D. Vet. Parasitol. (1998) [Pubmed]
  6. Humoral immune responses to Theileria parva in cattle as measured by two-dimensional western blotting. Kishima, M., Dolan, T.T., Njamunggeh, R.E., Nkonge, C.G., Spooner, P.R. Parasitol. Res. (1995) [Pubmed]
  7. Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva. Toye, P.G., Goddeeris, B.M., Iams, K., Musoke, A.J., Morrison, W.I. Parasite Immunol. (1991) [Pubmed]
  8. Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4(+) cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva. Graham, S.P., Saya, R., Awino, E., Ngugi, D., Nyanjui, J.K., Hecker, R., Taracha, E.L., Nene, V. Vet. Immunol. Immunopathol. (2007) [Pubmed]
  9. Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM). Skilton, R.A., Bishop, R.P., Wells, C.W., Spooner, P.R., Gobright, E., Nkonge, C., Musoke, A.J., Macklin, M., Iams, K.P. Parasitology (1998) [Pubmed]
  10. Characterisation of Theileria parva isolates from Kiambu district, Kenya. Matete, G.O., Kanyari, P.W., Ngatia, T.A., Karuiki, D.P., Ndung'u, S.G. Vet. Parasitol. (2004) [Pubmed]
  11. An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule. Katende, J., Morzaria, S., Toye, P., Skilton, R., Nene, V., Nkonge, C., Musoke, A. Parasitol. Res. (1998) [Pubmed]
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