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Gene Review:

TP04_0051 - polymorphic immunodominant molecule

Theileria parva strain Muguga

Toye, P.G. et al., Schnittger, L. et al., Skilton, R.A. et al., Graham, S.P. et al., Geysen, D. et al., et al.

Matete, Kanyari, Ngatia, Karuiki, Ndung'u, Geysen, Bazarusanga, Brandt, Dolan, Graham, Saya, Awino, Ngugi, Nyanjui, Hecker, Taracha, Nene, Honda, Matsubara, Morzaria, McKeever, Schnittger, Katzer, Biermann, Shayan, Boguslawski, McKellar, Beyer, Shiels, Ahmed, Skilton, Bishop, Wells, Spooner, Gobright, Nkonge, Musoke, Macklin, Iams,

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Disease relevance of TP04_0051

Finally, we showed that polyclonal rat Abs against recombinant PIM neutralize sporozoite infectivity in vitro, suggesting that the PIM Ag should be evaluated for its capacity to immunize cattle against East Coast Fever [1].

High impact information on TP04_0051

Here we show that mAb specific for the PIM Ag can inhibit sporozoite invasion of lymphocytes in vitro [1].
In the Muguga form of the molecule, there were five tandem repeats of the tetrapeptide, QPEP, that were shown, by transfection of a deleted version of the PIM gene, not to react with several anti-PIM mAbs [1].
The major schizont surface protein is the polymorphic immunodominant molecule, PIM, which contains a large glutamine- and proline-rich domain (QP-rd) that protrudes into the host cell cytoplasm [2].
Genetic diversity and structural organisation of the polymorphic immunodominant molecule (PIM) gene of the protozoan parasite Theileria parva was studied in isolates from sympatric and allopatric areas [3].
High identity of the N- and C-terminal regions with the polymorphic immunodominant molecule (PIM) of Theileria parva (identity of 93%), the existence of a central polymorphic region and two short introns within genomic clones suggest that the presented gene/protein may be the T. annulata homologue of PIM [4].

Biological context of TP04_0051

The immunohistochemical staining with anti-PIM mAb was found to be a useful tool for analysis of T. parva infection kinetics in cattle [5].
Isoelectric points of a polymorphic immunodominant molecule (PIM) of schizonts that induces strong antibody responses in cattle ranged from acidic to basic [6].

Anatomical context of TP04_0051

Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva [7].
Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4(+) cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva [8].

Analytical, diagnostic and therapeutic context of TP04_0051

Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM) [9].
Characterization of a polymorphic Theileria annulata surface protein (TaSP) closely related to PIM of Theileria parva: implications for use in diagnostic tests and subunit vaccines [4].
Immunoelectron microscopy demonstrated that the p150 antigen, like PIM, is located in the microspheres of the sporozoites and is exocytosed following sporozoite invasion of the host lymphocyte [9].
The western blot analysis revealed a greater heterogeneity in the molecular mass (M(r)) of PIM than previously thought [10].
An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule [11].

References

Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva. Toye, P.G., Metzelaar, M.J., Wijngaard, P.L., Nene, V., Iams, K., Roose, J., Nyanjui, J.K., Gobright, E., Musoke, A.J., Clevers, H.C. J. Immunol. (1995) [Pubmed]
Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM. Casanova, C.L., Xue, G., Taracha, E.L., Dobbelaere, D.A. Mol. Biochem. Parasitol. (2006) [Pubmed]
An unusual mosaic structure of the PIM gene of Theileria parva and its relationship to allelic diversity. Geysen, D., Bazarusanga, T., Brandt, J., Dolan, T.T. Mol. Biochem. Parasitol. (2004) [Pubmed]
Characterization of a polymorphic Theileria annulata surface protein (TaSP) closely related to PIM of Theileria parva: implications for use in diagnostic tests and subunit vaccines. Schnittger, L., Katzer, F., Biermann, R., Shayan, P., Boguslawski, K., McKellar, S., Beyer, D., Shiels, B.R., Ahmed, J.S. Mol. Biochem. Parasitol. (2002) [Pubmed]
Immunohistochemical detection of parasite antigens in Theileria parva-infected bovine lymphocytes. Honda, Y., Matsubara, Y., Morzaria, S., McKeever, D. Vet. Parasitol. (1998) [Pubmed]
Humoral immune responses to Theileria parva in cattle as measured by two-dimensional western blotting. Kishima, M., Dolan, T.T., Njamunggeh, R.E., Nkonge, C.G., Spooner, P.R. Parasitol. Res. (1995) [Pubmed]
Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva. Toye, P.G., Goddeeris, B.M., Iams, K., Musoke, A.J., Morrison, W.I. Parasite Immunol. (1991) [Pubmed]
Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4(+) cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva. Graham, S.P., Saya, R., Awino, E., Ngugi, D., Nyanjui, J.K., Hecker, R., Taracha, E.L., Nene, V. Vet. Immunol. Immunopathol. (2007) [Pubmed]
Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM). Skilton, R.A., Bishop, R.P., Wells, C.W., Spooner, P.R., Gobright, E., Nkonge, C., Musoke, A.J., Macklin, M., Iams, K.P. Parasitology (1998) [Pubmed]
Characterisation of Theileria parva isolates from Kiambu district, Kenya. Matete, G.O., Kanyari, P.W., Ngatia, T.A., Karuiki, D.P., Ndung'u, S.G. Vet. Parasitol. (2004) [Pubmed]
An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule. Katende, J., Morzaria, S., Toye, P., Skilton, R., Nene, V., Nkonge, C., Musoke, A. Parasitol. Res. (1998) [Pubmed]

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