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Gene Review

atl-1  -  Protein ATL-1

Caenorhabditis elegans

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Disease relevance of atl-1


High impact information on atl-1

  • Correspondingly, defects in Ubc5(let-70) or the DNA damage checkpoint genes atl-1 or mre-11 abolish CeBCD-dependent ubiquitylation in vivo [2].
  • Here, we show that atl-1 (Caenorhabditis elegans ATR) and rad-5/clk-2 prevent mitotic catastrophe, function in the S-phase checkpoint and also cooperate with atm-1 in the checkpoint response to DSBs after ionizing radiation (IR) to induce cell cycle arrest or apoptosis via the cep-1(p53)/egl-1 pathway [3].
  • How anterior-posterior (A-P) polarity cues control this asynchrony remains to be elucidated.RESULTS: We establish that early C. elegans embryos possess a hitherto unrecognized DNA replication checkpoint that relies on the PI-3-like kinase atl-1 and the kinase chk-1 [4].
  • In summary, Ce-atl-1 appears to be important for early embryogenesis, and loss of its function results in a defect in chromosome segregation, similar to what has been observed for AT-related proteins [5].
  • Gene expression analyses indicated that Ce-atl-1 mRNA was expressed in all larval stages and that its level increased about fivefold in the adult stage [5].

Biological context of atl-1


Anatomical context of atl-1

  • Ce-atl-1 was strongly expressed in both the mitotic and meiotic cells of adult gonads [5].


  1. Efficient repair of DNA damage induced by heavy ion particles in meiotic prophase I nuclei of Caenorhabditis elegans. Takanami, T., Zhang, Y., Aoki, H., Abe, T., Yoshida, S., Takahashi, H., Horiuchi, S., Higashitani, A. J. Radiat. Res. (2003) [Pubmed]
  2. A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. Polanowska, J., Martin, J.S., Garcia-Muse, T., Petalcorin, M.I., Boulton, S.J. EMBO J. (2006) [Pubmed]
  3. Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. Garcia-Muse, T., Boulton, S.J. EMBO J. (2005) [Pubmed]
  4. Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Brauchle, M., Baumer, K., Gönczy, P. Curr. Biol. (2003) [Pubmed]
  5. Characterization of Ce-atl-1, an ATM-like gene from Caenorhabditis elegans. Aoki, H., Sato, S., Takanami, T., Ishihara, T., Katsura, I., Takahashi, H., Higashitani, A. Mol. Gen. Genet. (2000) [Pubmed]
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