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Gene Review

HSP90  -  heat shock protein; similar to P.anserina...

Candida albicans SC5314

 
 
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Disease relevance of CaO19.6515

  • Enolase and Aspergillus HSP90 were detected also; their homologues in Candida albicans have been tested as vaccines and have been reported to provide a partially protective response against invasive candidiasis in mice [1].
 

High impact information on CaO19.6515

  • Proteins related to the hsp70 and hsp90 families of conserved stress proteins and some glycolytic enzyme proteins are also found in the cell wall, apparently as bona fide components [2].
  • In silico comparison of the SRE1/2 with the promoter sequences of other MDR (CDR2 and PDR5) and non-MDR (HSP90) steroid-responsive genes revealed a similarity with respect to conservation of three 5 bp stretches (AAGAA, CCGAA and ATTGG) [3].
  • The cytoplasmic protein bands were heat inducible and appeared to be estrogen induced as well, suggesting that C. albicans modulates hsp90 expression in response to environmental changes [4].
  • Candida albicans hsp90 has a mass of 82 -Da and has previously been implicated as a virulence factor [4].
  • Hsp90 is a stress-induced protein involved in many cellular processes including the regulation of signal transduction and steroid hormone response pathways in higher eukaryotic cells [4].
 

Analytical, diagnostic and therapeutic context of CaO19.6515

References

  1. Fungal antigens expressed during invasive aspergillosis. Denikus, N., Orfaniotou, F., Wulf, G., Lehmann, P.F., Monod, M., Reichard, U. Infect. Immun. (2005) [Pubmed]
  2. Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Chaffin, W.L., López-Ribot, J.L., Casanova, M., Gozalbo, D., Martínez, J.P. Microbiol. Mol. Biol. Rev. (1998) [Pubmed]
  3. SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter. Karnani, N., Gaur, N.A., Jha, S., Puri, N., Krishnamurthy, S., Goswami, S.K., Mukhopadhyay, G., Prasad, R. Yeast (2004) [Pubmed]
  4. Isolation and partial characterization of Hsp90 from Candida albicans. Burt, E.T., Daly, R., Hoganson, D., Tsirulnikov, Y., Essmann, M., Larsen, B. Ann. Clin. Lab. Sci. (2003) [Pubmed]
  5. Comparison of protective effect of protein and DNA vaccines hsp90 in murine model of systemic candidiasis. Raska, M., Beláková, J., Wudattu, N.K., Kafková, L., Růzicková, K., Sebestová, M., Kolár, Z., Weigl, E. Folia Microbiol. (Praha) (2005) [Pubmed]
 
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