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Gene Review

tum  -  tumbleweed

Drosophila melanogaster

Synonyms: 13345, AcGAP, CG13345, DRacGAP, Dmel\CG13345, ...
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High impact information on RacGAP50C


Biological context of RacGAP50C


Anatomical context of RacGAP50C


Other interactions of RacGAP50C

  • Two mutant lines that modify wg-mediated epidermal patterning represent the first loss-of-function mutations in the RacGap50C gene [4].
  • Only one RacGAP protein, RnRacGAP, has been identified in Drosophila [7].
  • Cellular studies have shown that RacGAP proteins function as negative regulators of substrate Rac proteins which, in turn, control the localization and polymerization state of actin within the cell [8].


  1. Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. D'Avino, P.P., Savoian, M.S., Glover, D.M. J. Cell Biol. (2004) [Pubmed]
  2. Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Goldstein, A.Y., Jan, Y.N., Luo, L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. Zavortink, M., Contreras, N., Addy, T., Bejsovec, A., Saint, R. J. Cell. Sci. (2005) [Pubmed]
  4. RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. Jones, W.M., Bejsovec, A. Genetics (2005) [Pubmed]
  5. DRacGAP, a novel Drosophila gene, inhibits EGFR/Ras signalling in the developing imaginal wing disc. Sotillos, S., Campuzano, S. Development (2000) [Pubmed]
  6. A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. Somers, W.G., Saint, R. Dev. Cell (2003) [Pubmed]
  7. Overexpression of RnRacGAP in Drosophila melanogaster deregulates cytoskeletal organisation in cellularising embryos and induces discrete imaginal phenotypes. Guichard, A., Bergeret, E., Griffin-Shea, R. Mech. Dev. (1997) [Pubmed]
  8. Alternative splicing of the Drosophila melanogaster rotundRacGAP gene. Hoemann, C.D., Bergeret, E., Guichard, A., Griffin-Shea, R. Gene (1996) [Pubmed]
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