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Gene Review

scb  -  scab

Drosophila melanogaster

Synonyms: CG8095, CT21280, CT36929, Dm0620, Dmel\CG8095, ...
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Psychiatry related information on scb


High impact information on scb

  • The Volado gene is expressed preferentially in mushroom body cells, which are neurons known to mediate olfactory learning in insects [2].
  • Thus the Volado integrin is essential for the physiological processes underlying memory [2].
  • Volado proteins are concentrated in the mushroom body neuropil, brain areas that contain mushroom body processes in synaptic contact with other neurons [2].
  • Conditional expression of a Volado transgene during adulthood rescues the memory impairment [2].
  • Having generated the tools to eliminate integrin function completely, we confirm that Drosophila integrins do not control proliferation as they do in mammals, and have identified alphaPS3 as a heterodimeric partner for betanu [3].

Biological context of scb

  • We report the temporal expression of the gene encoding this integrin subunit, which we have called alphaPS3, throughout development and the localization of its expression during embryogenesis [4].

Anatomical context of scb


  1. Integrin-mediated regulation of synaptic morphology, transmission, and plasticity. Rohrbough, J., Grotewiel, M.S., Davis, R.L., Broadie, K. J. Neurosci. (2000) [Pubmed]
  2. Integrin-mediated short-term memory in Drosophila. Grotewiel, M.S., Beck, C.D., Wu, K.H., Zhu, X.R., Davis, R.L. Nature (1998) [Pubmed]
  3. Morphogenesis in the absence of integrins: mutation of both Drosophila beta subunits prevents midgut migration. Devenport, D., Brown, N.H. Development (2004) [Pubmed]
  4. A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Stark, K.A., Yee, G.H., Roote, C.E., Williams, E.L., Zusman, S., Hynes, R.O. Development (1997) [Pubmed]
  5. Differentiation, extracellular matrix synthesis, and integrin assembly by Drosophila embryo cells cultured on vitronectin and laminin substrates. Gullberg, D., Fessler, L.I., Fessler, J.H. Dev. Dyn. (1994) [Pubmed]
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