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Gene Review

LanB1  -  CG7123 gene product from transcript CG7123-RA

Drosophila melanogaster

Synonyms: BcDNA:LD21794, CG7123, CT22015, Dmel\CG7123, EP-600, ...
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Disease relevance of LanB1

  • These results suggest that DGNBP-1 functions as a pattern recognition receptor for LPS from Gram-negative bacteria and beta-1, 3-glucan from fungi and plays an important role in non-self recognition and the subsequent immune signal transmission for the induction of antimicrobial peptide genes in the Drosophila innate immune system [1].
  • Interaction of Bombyx mori nucleopolyhedrovirus BRO-A and host cell protein laminin [2].
  • Generalized epilepsy with febrile seizures plus type 1 is an inherited human epileptic syndrome, associated with a cysteine-to-tryptophan (C121W) mutation in the extracellular immunoglobin domain of the auxiliary beta1 subunit of the voltage-gated sodium channel [3].

High impact information on LanB1


Biological context of LanB1


Anatomical context of LanB1


Associations of LanB1 with chemical compounds

  • alpha-, beta- or gamma-chain-specific RNA interference of laminin assembly in Drosophila Kc167 cells [10].
  • Further, we show that neurotic is required for Fringe activity, which encodes a fucose-specific beta1, 3 N-acetylglucosaminyltransferase, previously shown to modulate Notch receptor activity [17].
  • We hypothesized that a tyrosine residue in the cytoplasmic domain of beta 1 may be important for ankyrin recruitment and tested our hypothesis using beta 1 mutants replacing Tyr(181) with alanine (beta 1Y181A), phenylalanine (beta 1Y181F), or glutamate (beta 1Y181E), or a truncated construct deleting all residues beyond Tyr(181) (beta 1L182(STOP)) [18].
  • 6. Etomidate acting at beta1 (S290)-containing mammalian GABA(A) receptors is known to produce only a modest GABA-modulatory effect [19].
  • Two-dimensional gel electrophoresis separated at least 28 proteins, 13 of which were identified with monospecific antibodies to alpha6/C2 (five species), alpha2/C3 (three species), alpha7/C8 (three species), alpha5/zeta, and beta1/Y subunits [20].

Other interactions of LanB1


Analytical, diagnostic and therapeutic context of LanB1


  1. Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. Kim, Y.S., Ryu, J.H., Han, S.J., Choi, K.H., Nam, K.B., Jang, I.H., Lemaitre, B., Brey, P.T., Lee, W.J. J. Biol. Chem. (2000) [Pubmed]
  2. Interaction of Bombyx mori nucleopolyhedrovirus BRO-A and host cell protein laminin. Kang, W.K., Imai, N., Suzuki, M., Iwanaga, M., Matsumoto, S., Zemskov, E.A. Arch. Virol. (2003) [Pubmed]
  3. Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. Meadows, L.S., Malhotra, J., Loukas, A., Thyagarajan, V., Kazen-Gillespie, K.A., Koopman, M.C., Kriegler, S., Isom, L.L., Ragsdale, D.S. J. Neurosci. (2002) [Pubmed]
  4. Drosophila substrate adhesion molecule: sequence of laminin B1 chain reveals domains of homology with mouse. Montell, D.J., Goodman, C.S. Cell (1988) [Pubmed]
  5. Retraction of the Drosophila germ band requires cell-matrix interaction. Schöck, F., Perrimon, N. Genes Dev. (2003) [Pubmed]
  6. Laminin in the male germ cells of Drosophila. Wang, F., Hanske, M., Miedema, K., Klein, G., Ekblom, P., Hennig, W. J. Cell Biol. (1992) [Pubmed]
  7. (AT)n is an interspersed repeat in the Xenopus genome. Greaves, D.R., Patient, R.K. EMBO J. (1985) [Pubmed]
  8. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Poulton, J.S., Deng, W.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Cloning and biological function of laminin in Hydra vulgaris. Sarras, M.P., Yan, L., Grens, A., Zhang, X., Agbas, A., Huff, J.K., St John, P.L., Abrahamson, D.R. Dev. Biol. (1994) [Pubmed]
  10. alpha-, beta- or gamma-chain-specific RNA interference of laminin assembly in Drosophila Kc167 cells. Goto, A., Aoki, M., Ichihara, S., Kitagawa, Y. Biochem. J. (2001) [Pubmed]
  11. Analysis of the Drosophila gene for the laminin B1 chain. Gow, C.H., Chang, H.Y., Lih, C.J., Chang, T.W., Hui, C.F. DNA Cell Biol. (1993) [Pubmed]
  12. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
  13. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. De Luca, L.M. FASEB J. (1991) [Pubmed]
  14. Axoneme-specific beta-tubulin specialization: a conserved C-terminal motif specifies the central pair. Nielsen, M.G., Turner, F.R., Hutchens, J.A., Raff, E.C. Curr. Biol. (2001) [Pubmed]
  15. Junctional adhesion molecules (JAMs): more molecules with dual functions? Ebnet, K., Suzuki, A., Ohno, S., Vestweber, D. J. Cell. Sci. (2004) [Pubmed]
  16. In situ hybridization reveals transient laminin B-chain expression by individual glial and muscle cells in embryonic leech central nervous system. Luebke, A.E., Dickerson, I.M., Muller, K.J. J. Neurobiol. (1995) [Pubmed]
  17. neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Sasamura, T., Sasaki, N., Miyashita, F., Nakao, S., Ishikawa, H.O., Ito, M., Kitagawa, M., Harigaya, K., Spana, E., Bilder, D., Perrimon, N., Matsuno, K. Development (2003) [Pubmed]
  18. Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin. Malhotra, J.D., Koopmann, M.C., Kazen-Gillespie, K.A., Fettman, N., Hortsch, M., Isom, L.L. J. Biol. Chem. (2002) [Pubmed]
  19. The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor. McGurk, K.A., Pistis, M., Belelli, D., Hope, A.G., Lambert, J.J. Br. J. Pharmacol. (1998) [Pubmed]
  20. Subunit compositions and catalytic properties of proteasomes from developmental temperature- sensitive mutants of Drosophila melanogaster. Covi, J.A., Belote, J.M., Mykles, D.L. Arch. Biochem. Biophys. (1999) [Pubmed]
  21. Two Drosophila genes that encode the alph and beta subunits of the brain soluble guanylyl cyclase. Shah, S., Hyde, D.R. J. Biol. Chem. (1995) [Pubmed]
  22. During Drosophila spermatogenesis beta 1, beta 2 and beta 3 tubulin isotypes are cell-type specifically expressed but have the potential to coassemble into the axoneme of transgenic flies. Kaltschmidt, B., Glätzer, K.H., Michiels, F., Leiss, D., Renkawitz-Pohl, R. Eur. J. Cell Biol. (1991) [Pubmed]
  23. Muscle development and attachment to the epidermis is accompanied by expression of beta 3 and beta 1 tubulin isotypes, respectively. Buttgereit, D., Paululat, A., Renkawitz-Pohl, R. Int. J. Dev. Biol. (1996) [Pubmed]
  24. Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues. Miner, J.H., Lewis, R.M., Sanes, J.R. J. Biol. Chem. (1995) [Pubmed]
  25. The beta-tubulin gene family evolution in the Drosophila montium subgroup of the melanogaster species group. Drosopoulou, E., Scouras, Z.G. J. Mol. Evol. (1995) [Pubmed]
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