The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

pAbp  -  CG5119 gene product from transcript CG5119-RC

Drosophila melanogaster

Synonyms: BcDNA:LD24412, CG16803, CG5119, Dmel\CG5119, PABP, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on pAbp

  • Genetic models of junctional plasticity and genetic manipulations using the translation initiation factors eIF4E and poly(A)-binding protein showed an increased occurrence of subsynaptic translation aggregates [1].
  • Here, we demonstrate that ataxin-2 and its Drosophila homolog, ATX2, assemble with polyribosomes and poly(A)-binding protein (PABP), a key regulator of mRNA translation [2].
  • The assembly of ATX2 with polyribosomes is mediated independently by two distinct evolutionarily conserved regions of ATX2: an N-terminal Lsm/Lsm-associated domain (LsmAD), found in proteins that function in nuclear RNA processing and mRNA decay, and a PAM2 motif, found in proteins that interact physically with PABP [2].
  • The PABP transcript accumulates in oocytes, is maternally inherited by the embryo and present at every other developmental stage tested [3].
  • Two classes of cDNAs encoding the Drosophila melanogaster (poly(A)-binding protein (PABP), which differ in length due to different positions of their respective 3' ends, were isolated by screening an embryonic cDNA library [3].
 

Anatomical context of pAbp

  • We further show that the PAM2 motif mediates a physical interaction of ATX2 with PABP in addition to promoting ATX2 assembly with polyribosomes [2].
  • KLP10A and KLP59C: the dynamic duo of microtubule depolymerization [4].
 

Analytical, diagnostic and therapeutic context of pAbp

  • A FLAG-tagged poly(A)-binding protein (PABP) is expressed in a specific tissue and mRNA from that tissue is thus tagged by the recombinant PABP and separated from mRNA in other tissues by co-immunoprecipitation with a FLAG-tag specific antibody [5].

References

  1. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Sigrist, S.J., Thiel, P.R., Reiff, D.F., Lachance, P.E., Lasko, P., Schuster, C.M. Nature (2000) [Pubmed]
  2. Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes. Satterfield, T.F., Pallanck, L.J. Hum. Mol. Genet. (2006) [Pubmed]
  3. Drosophila melanogaster poly(A)-binding protein: cDNA cloning reveals an unusually long 3'-untranslated region of the mRNA, also present in other eukaryotic species [corrected]. Lefrère, V., Vincent, A., Amalric, F. Gene (1990) [Pubmed]
  4. KLP10A and KLP59C: the dynamic duo of microtubule depolymerization. Sharp, D.J., Mennella, V., Buster, D.W. Cell Cycle (2005) [Pubmed]
  5. Isolation of mRNA from specific tissues of Drosophila by mRNA tagging. Yang, Z., Edenberg, H.J., Davis, R.L. Nucleic Acids Res. (2005) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities