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Gene Review

PABPC4  -  poly(A) binding protein, cytoplasmic 4...

Homo sapiens

Synonyms: APP-1, APP1, Activated-platelet protein 1, Inducible poly(A)-binding protein, PABP-4, ...
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Disease relevance of PABPC4


Psychiatry related information on PABPC4

  • To better understand the role the human amyloid precursor protein (hAPP) plays in Alzheimer's disease (AD), it is essential to define its primary function(s) [4].

High impact information on PABPC4

  • iPABP, an inducible poly(A)-binding protein detected in activated human T cells [5].
  • In contrast, PABP is constitutively expressed in both resting and activated T cells. iPABP mRNA was also expressed at much higher levels than PABP mRNA in heart and skeletal muscle tissue [5].
  • Next, using the luciferase reporter assay in both C. neoformans wild-type and GAL7:IPC1 strains, we investigated the role of DAG and sphingolipids in the activation of the APP1 promoter and found that treatment with 1,2-dioctanoylglycerol does increase APP1 transcription, whereas treatment with phytosphingosine or ceramides does not [6].
  • Two putative consensus sequences were found in the APP1 promoter for ATF and AP-2 transcription factors [6].
  • Mutagenesis analysis of these sequences revealed that they play a key role in the regulation of APP1 transcription: ATF is an activator, whereas AP-2 in a negative regulator [6].

Chemical compound and disease context of PABPC4


Biological context of PABPC4

  • The iPABP gene has been assigned to chromosome 1 [8].
  • The pseudogenes PABP4, 1, and 2 have been assigned to chromosomes 15, 4, and 14, respectively [8].
  • Here, we identified two types of cDNA clones coding for poly(A)-binding protein (PABP) and inducible PABP (iPABP) by screening an expression cDNA library with the GST-Tob probe [9].
  • Consistently, over-expression of Tob in NIH3T3 cells, in which exogenous iPABP was stably expressed, resulted in suppression of IL-2 production from the simultaneously transfected IL-2 expression plasmid [9].
  • The full-length cDNA coding for human APP-1, obtained by DNA hybridization techniques, showed 98.7% amino acid sequence identity with the rabbit protein [10].

Anatomical context of PABPC4

  • A 2.3-kb cDNA fragment containing a partial coding sequence for APP-1 was isolated from a rabbit bone marrow library by expression cloning with the anti-APP-1 monoclonal antibody [10].
  • By virtue of its ribonucleotide binding domains, APP-1 is structurally related to polyadenylate-binding protein, which regulates translation initiation and polyadenylate shortening, and to nucleolysin, a specific effector molecule found in the granules of cytotoxic T lymphocytes [10].
  • Human amyloid precursor protein (hAPP) transgenic mice with high levels of amyloid-beta (Abeta) develop behavioral deficits that correlate with the depletion of synaptic activity-related proteins in the dentate gyrus [7].

Other interactions of PABPC4


Analytical, diagnostic and therapeutic context of PABPC4


  1. Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. Vassbotn, F.S., Ostman, A., Langeland, N., Holmsen, H., Westermark, B., Heldin, C.H., Nistér, M. J. Cell. Physiol. (1994) [Pubmed]
  2. Activated platelet aggregates in thrombotic thromboctyopenic purpura: decrease with plasma infusions and normalization in remission. Ahn, Y.S., Jy, W., Kolodny, L., Horstman, L.L., Mao, W.W., Valant, P.A., Duncan, R.C. Br. J. Haematol. (1996) [Pubmed]
  3. Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions. Erşahin, C., Szpaderska, A.M., Orawski, A.T., Simmons, W.H. Arch. Biochem. Biophys. (2005) [Pubmed]
  4. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Mucke, L., Abraham, C.R., Masliah, E. Ann. N. Y. Acad. Sci. (1996) [Pubmed]
  5. iPABP, an inducible poly(A)-binding protein detected in activated human T cells. Yang, H., Duckett, C.S., Lindsten, T. Mol. Cell. Biol. (1995) [Pubmed]
  6. APP1 transcription is regulated by inositol-phosphorylceramide synthase 1-diacylglycerol pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans. Mare, L., Iatta, R., Montagna, M.T., Luberto, C., Del Poeta, M. J. Biol. Chem. (2005) [Pubmed]
  7. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. Chin, J., Palop, J.J., Puoliväli, J., Massaro, C., Bien-Ly, N., Gerstein, H., Scearce-Levie, K., Masliah, E., Mucke, L. J. Neurosci. (2005) [Pubmed]
  8. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. Féral, C., Mattéi, M.G., Pawlak, A., Guellaën, G. Hum. Genet. (1999) [Pubmed]
  9. Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. Okochi, K., Suzuki, T., Inoue, J., Matsuda, S., Yamamoto, T. Genes Cells (2005) [Pubmed]
  10. Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets. Houng, A.K., Maggini, L., Clement, C.Y., Reed, G.L. Eur. J. Biochem. (1997) [Pubmed]
  11. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. Blanco, P., Sargent, C.A., Boucher, C.A., Howell, G., Ross, M., Affara, N.A. Genomics (2001) [Pubmed]
  12. Modulation of KGF-1 gene expression in oral fibroblasts by ripe areca nut extract. Ko, S.Y., Lin, S.C., Chang, K.W., Liu, C.J., Chang, S.S., Lu, S.Y., Liu, T.Y. J. Oral Pathol. Med. (2003) [Pubmed]
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