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Gene Review

edl  -  ETS-domain lacking

Drosophila melanogaster

Synonyms: CG15085, Dmel\CG15085, EDL, Edl, MAE, ...
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High impact information on edl


Biological context of edl


Anatomical context of edl

  • The loss of EDL/MAE function results in reduced number of photoreceptor neurons and chordotonal organs, suggesting a positive role in the induction by Spitz EGF [4].

Physical interactions of edl

  • Mae binding to Pnt-P2 occludes this docking surface, thereby acting to downregulate Pnt-P2 activity [5].

Regulatory relationships of edl

  • We propose that EDL/MAE blocks autocrine activation of Pointed P2 so that inducing cells remain induction-competent [4].

Other interactions of edl

  • We describe developmental roles of a novel negative regulator of Ras signaling, EDL/MAE, a protein with an Ets-specific Pointed domain but not an ETS DNA-binding domain [4].
  • Derepression by depolymerization; structural insights into the regulation of Yan by Mae [1].


  1. Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Qiao, F., Song, H., Kim, C.A., Sawaya, M.R., Hunter, J.B., Gingery, M., Rebay, I., Courey, A.J., Bowie, J.U. Cell (2004) [Pubmed]
  2. Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila. Baker, D.A., Mille-Baker, B., Wainwright, S.M., Ish-Horowicz, D., Dibb, N.J. Nature (2001) [Pubmed]
  3. Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Song, H., Nie, M., Qiao, F., Bowie, J.U., Courey, A.J. Genes Dev. (2005) [Pubmed]
  4. EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed. Yamada, T., Okabe, M., Hiromi, Y. Development (2003) [Pubmed]
  5. Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site. Qiao, F., Harada, B., Song, H., Whitelegge, J., Courey, A.J., Bowie, J.U. EMBO J. (2006) [Pubmed]
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