Disease relevance of Ets97D

• Ets factors regulate the polycystic kidney disease-1 promoter [1].
• Ets genes also have a role in T-cell development and molecular and genetic analysis of Down Syndrome patients have implicated the human Ets-2 and Erg genes in the disease [2].
• Ets genes are involved in certain chromosomal translocations leading to the formation of chimeric fusion proteins that are associated with certain leukemias and soft tissue cancers [2].

High impact information on Ets97D

• The Drosophila gene pointed (pnt) encodes two putative transcription factors (P1 and P2) of the Ets family, which in the embryonic CNS are found exclusively in glial cells [3].
• The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS [3].
• Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila [4].
• Ets oncogene-related gene Elg functions in Drosophila oogenesis [5].
• The mutation of a highly conserved tyrosine residue in the ETS DNA-binding domain of the Elg gene product demonstrates that normal gene function is required for proper follicle cell migration, chorion formation, and nurse cell-chromosome decondensation during Drosophila oogenesis [5].

Biological context of Ets97D

• Here we report the cloning and characterization of a new component of this signal transduction pathway called Mae (for modulator of the activity of Ets) [4].
• Characterization of lethal alleles of D-elg, an ets proto-oncogene related gene with multiple functions in Drosophila development [6].
• The D-elg gene is located at 97D on chromosome 3R and is expressed as a 2.0kb RNA in the embryos, pupae and adults, with no detectable expression in third instar larvae [7].
• D-elg expression is observed in all cells of early stage embryos, prior to transcriptional activation of the zygotic genome, and is maintained throughout embryogenesis with no regional localization [7].
• Consistent with these phenotypes, D-elg shows genetic interactions with two genes required for normal egg chamber differentiation [8].

Anatomical context of Ets97D

• Two well-characterized Ets family members, Ets-1 and Ets-2, are reciprocally expressed during T-cell activation [9].

Regulatory relationships of Ets97D

• EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed [10].

Other interactions of Ets97D

• D-ets-4 and D-elg are expressed at their highest levels in the pole cells, suggesting a role in the development of the germline [11].

Analytical, diagnostic and therapeutic context of Ets97D

• Gel shift analysis showed that Ets and Sp1 family members bound to these sites [12].
• Site-specific mutagenesis and transfection studies revealed that this region contains two consensus Ets sites and a single Sp1 site that were necessary for Pem Pd expression [12].

References