Gene Review:
BTK - Bruton agammaglobulinemia tyrosine kinase
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- SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells. Zhu, D.M., Tibbles, H.E., Vassilev, A.O., Uckun, F.M. Leuk. Lymphoma (2002)
- A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. Takata, M., Kurosaki, T. J. Exp. Med. (1996)
- Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction. Mukhopadhyay, S., George, A., Bal, V., Ravindran, B., Rath, S. J. Immunol. (1999)
- Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells. Goodman, P.A., Niehoff, L.B., Uckun, F.M. J. Biol. Chem. (1998)
- Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function. Kurosaki, T., Kurosaki, M. J. Biol. Chem. (1997)
- Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. Uckun, F., Ozer, Z., Vassilev, A. Br. J. Haematol. (2007)
- B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol. Antony, P., Petro, J.B., Carlesso, G., Shinners, N.P., Lowe, J., Khan, W.N. Biochem. Soc. Trans. (2004)
- Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases. Nore, B.F., Vargas, L., Mohamed, A.J., Brandén, L.J., Bäckesjö, C.M., Islam, T.C., Mattsson, P.T., Hultenby, K., Christensson, B., Smith, C.I. Eur. J. Immunol. (2000)