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Gene Review

OPTN  -  optineurin

Gallus gallus

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Disease relevance of OPTN


High impact information on OPTN

  • Remarkably, during erythroblast differentiation FIP-2 was found to translocate from the Golgi to the marginal band [2].
  • In contrast, disruption of both Golgi structure and function (by brefeldin A) led to a loss of FIP-2 from Golgi membranes [2].
  • Differential localization of chicken FIP2 homologue, Ag-9C5, in secretory epithelial cells [3].
  • Perturbation of the Golgi structure without loss of Golgi function (by treatment with nocodazole) resulted in a retention of FIP-2 at the dispersed Golgi fragments [2].
  • Moreover, our results raise the possibility that the marginal band of chicken erythrocytes, in addition to its role in morphogenesis, has a function in signal transduction and that FIP-2 is in some way involved in its formation [2].

Biological context of OPTN

  • We found that chicken FIP-2 was expressed in a variety of tissues and cell types, but unlike its human counterpart, alternative splicing does not appear to take place [2].
  • Using an antiserum directed against marginal band associated proteins of chicken erythrocytes we isolated clones encoding the chicken homolog of 14.7K-interacting protein 2 (FIP-2), a protein potentially involved in tumor necrosis factor-alpha/nuclear factor-kappaB signaling, from a chicken erythroblast cDNA library [2].


  1. Transgenic studies on the role of optineurin in the mouse eye. Kroeber, M., Ohlmann, A., Russell, P., Tamm, E.R. Exp. Eye Res. (2006) [Pubmed]
  2. FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation. Stroissnigg, H., Repitz, M., Miloloza, A., Linhartova, I., Beug, H., Wiche, G., Propst, F. Exp. Cell Res. (2002) [Pubmed]
  3. Differential localization of chicken FIP2 homologue, Ag-9C5, in secretory epithelial cells. Li, B., Gallin, W.J. Exp. Cell Res. (2002) [Pubmed]
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