Gene Review:
OPTN - optineurin
Homo sapiens
Synonyms:
ALS12, E3-14.7K-interacting protein, FIP-2, FIP2, GLC1E, ...
Kamphuis,
Tam,
Desai,
Warady,
Kamath,
Kim,
Sarfarazi,
Aeder,
Toomes,
Tamai,
Craig,
Seimiya,
Brice,
Edwards,
Lam,
Cherikh,
Lam,
Cheng,
Akiyama,
Wissinger,
Lake,
Bryan,
Wolfe,
Poinoosawmy,
Rezaie,
Sarfarazi,
Lau,
Neumann,
Shield,
Crick,
Weisschuh,
Nelson,
McBride,
Fan,
Wolf,
Cherikh,
Krom,
Fuse,
Dimasi,
Kremers,
Harper,
Takahashi,
Merion,
Wiesner,
Nakazawa,
Pang,
Stoilova,
Mackey,
Hanto,
Schneemann,
Trifan,
Freeman,
Kuwahara,
Winklhofer,
Kauffman,
Howell,
Gramer,
Fan,
Howard,
Muruve,
Cheng,
Cohn,
Child,
Wang,
Tham,
Hewitt,
- The role of TIGR and OPTN in Finnish glaucoma families: a clinical and molecular genetic study. Forsman, E., Lemmelä, S., Varilo, T., Kristo, P., Forsius, H., Sankila, E.M., Järvelä, I. Mol. Vis. (2003)
- SNPs and Interaction Analyses of Noelin 2, Myocilin, and Optineurin Genes in Japanese Patients with Open-Angle Glaucoma. Funayama, T., Mashima, Y., Ohtake, Y., Ishikawa, K., Fuse, N., Yasuda, N., Fukuchi, T., Murakami, A., Hotta, Y., Shimada, N. Invest. Ophthalmol. Vis. Sci. (2006)
- Optineurin in primary open angle glaucoma. Sarfarazi, M., Rezaie, T. Ophthalmology clinics of North America. (2003)
- The role of the Met98Lys optineurin variant in inherited optic nerve diseases. Craig, J.E., Hewitt, A.W., Dimasi, D.P., Howell, N., Toomes, C., Cohn, A.C., Mackey, D.A. The British journal of ophthalmology. (2006)
- Model for end-stage liver disease (MELD) and allocation of donor livers. Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P., Kremers, W., Lake, J., Howard, T., Merion, R.M., Wolfe, R.A., Krom, R. Gastroenterology (2003)
- Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. Sahlender, D.A., Roberts, R.C., Arden, S.D., Spudich, G., Taylor, M.J., Luzio, J.P., Kendrick-Jones, J., Buss, F. J. Cell Biol. (2005)
- Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region. Sarfarazi, M., Child, A., Stoilova, D., Brice, G., Desai, T., Trifan, O.C., Poinoosawmy, D., Crick, R.P. Am. J. Hum. Genet. (1998)
- Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Li, Y., Kang, J., Horwitz, M.S. Mol. Cell. Biol. (1998)
- Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein. Yamauchi, H., O'Neill, A., Gelman, R., Carney, W., Tenney, D.Y., Hösch, S., Hayes, D.F. J. Clin. Oncol. (1997)
- Different optineurin mutation pattern in primary open-angle glaucoma. Leung, Y.F., Fan, B.J., Lam, D.S., Lee, W.S., Tam, P.O., Chua, J.K., Tham, C.C., Lai, J.S., Fan, D.S., Pang, C.P. Invest. Ophthalmol. Vis. Sci. (2003)
- SNPs and interaction analyses of myocilin, optineurin, and apolipoprotein E in primary open angle glaucoma patients. Fan, B.J., Wang, D.Y., Fan, D.S., Tam, P.O., Lam, D.S., Tham, C.C., Lam, C.Y., Lau, T.C., Pang, C.P. Mol. Vis. (2005)
- Defining the pathogenicity of optineurin in juvenile open-angle glaucoma. Willoughby, C.E., Chan, L.L., Herd, S., Billingsley, G., Noordeh, N., Levin, A.V., Buys, Y., Trope, G., Sarfarazi, M., Héon, E. Invest. Ophthalmol. Vis. Sci. (2004)
- Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure. Vittitow, J., Borrás, T. Biochem. Biophys. Res. Commun. (2002)
- Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population. Fuse, N., Takahashi, K., Akiyama, H., Nakazawa, T., Seimiya, M., Kuwahara, S., Tamai, M. Journal of glaucoma. (2004)
- Optineurin gene expression level in human trabecular meshwork does not change in response to pressure elevation. Kamphuis, W., Schneemann, A. Ophthalmic Res. (2003)
- Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types. Park, B.C., Shen, X., Samaraweera, M., Yue, B.Y. Am. J. Pathol. (2006)
- ABO blood group influences a candidate's likelihood of receiving an HLA zero antigen mismatch kidney. Bryan, C.F., Cherikh, W.S., Cheng, Y., Aeder, M.I., Muruve, N.A., Nelson, P.W., Shield, C.F., Warady, B.A., Winklhofer, F.T. Clinical transplantation. (2004)
- Post-transplant de novo malignancies in renal transplant recipients: the past and present. Kauffman, H.M., Cherikh, W.S., McBride, M.A., Cheng, Y., Hanto, D.W. Transpl. Int. (2006)
- Identification of a transcription factor IIIA-interacting protein. Moreland, R.J., Dresser, M.E., Rodgers, J.S., Roe, B.A., Conaway, J.W., Conaway, R.C., Hanas, J.S. Nucleic Acids Res. (2000)
- FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Hattula, K., Peränen, J. Curr. Biol. (2000)
- Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma. Funayama, T., Ishikawa, K., Ohtake, Y., Tanino, T., Kurosaka, D., Kimura, I., Suzuki, K., Ideta, H., Nakamoto, K., Yasuda, N., Fujimaki, T., Murakami, A., Asaoka, R., Hotta, Y., Tanihara, H., Kanamoto, T., Mishima, H., Fukuchi, T., Abe, H., Iwata, T., Shimada, N., Kudoh, J., Shimizu, N., Mashima, Y. Invest. Ophthalmol. Vis. Sci. (2004)
- Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Zhu, G., Wu, C.J., Zhao, Y., Ashwell, J.D. Curr. Biol. (2007)
- Prevalence of myocilin and optineurin sequence variants in German normal tension glaucoma patients. Weisschuh, N., Neumann, D., Wolf, C., Wissinger, B., Gramer, E. Mol. Vis. (2005)
- Analysis of optineurin (OPTN) gene mutations in subjects with and without glaucoma: the Blue Mountains Eye Study. Baird, P.N., Richardson, A.J., Craig, J.E., Mackey, D.A., Rochtchina, E., Mitchell, P. Clin. Experiment. Ophthalmol. (2004)
- Similar risk profiles for post-transplant renal dysfunction and long-term graft failure: UNOS/OPTN database analysis. Siddiqi, N., McBride, M.A., Hariharan, S. Kidney Int. (2004)