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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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KCNB1  -  potassium channel, voltage gated Shab...

Homo sapiens

Synonyms: DRK1, Delayed rectifier potassium channel 1, EIEE26, KV2.1, Kv2.1, ...
 
 
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High impact information on KCNB1

  • To further examine the secondary structure of the COOH terminus of S3, we lysine-scanned this region in the drk1 K(+) channel and examined the mutation-induced changes in channel gating and Hanatoxin binding affinity, looking for periodicity characteristic of an alpha-helix [1].
  • 1. The human delayed rectifier K+ channel h-DRK1, a homologue to the DRK1 channel in the rat, was expressed in Xenopus oocytes [2].
  • Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling [3].
  • A nonconservative amino acid substitution (Ser857Asn) in the human delayed-rectifier potassium channel DRK1 (KCNB1 locus), a candidate gene for the low voltage alpha electroencephalogram (EEG) trait locus (LVEEG1) at 20q13.2, and its frequency in ethnic population samples are described [4].
  • Three functional candidate genes (B4GALT5, KCNB1, and PTGIS) were sequenced [5].
 

Biological context of KCNB1

  • No mutations were discovered in the coding regions of these three genes and the promoter regions of B4GALT5 and KCNB1 genes [5].
  • Introduction of a cadmium (Cd(2+))-binding site in the external vestibule of Kv2.1 (drk1), allowed us to functionally characterize a binding site for external monovalent cations [6].
 

Anatomical context of KCNB1

  • KV2.1 K+ channels underlie major voltage-gated K+ outward current in H9c2 myoblasts [7].

References

  1. Helical structure of the COOH terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels. Li-Smerin, Y., Swartz, K.J. J. Gen. Physiol. (2001) [Pubmed]
  2. Gating and conductance properties of a human delayed rectifier K+ channel expressed in frog oocytes. Benndorf, K., Koopmann, R., Lorra, C., Pongs, O. J. Physiol. (Lond.) (1994) [Pubmed]
  3. Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling. Tamarina, N.A., Kuznetsov, A., Fridlyand, L.E., Philipson, L.H. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  4. Identification of a Ser857-Asn857 substitution in DRK1 (KCNB1), population frequencies and lack of association to the low voltage alpha EEG trait. Mazzanti, C.M., Bergen, A., Enoch, M.A., Michelini, S., Goldman, D. Hum. Genet. (1996) [Pubmed]
  5. A family exhibiting arterial tortuosity syndrome displays homozygosity for markers in the arterial tortuosity locus at chromosome 20q13. Zaidi, S.H., Peltekova, V., Meyer, S., Lindinger, A., Paterson, A.D., Tsui, L.C., Faiyaz-Ul-Haque, M., Teebi, A.S. Clin. Genet. (2005) [Pubmed]
  6. Allosteric effects of external K(+) ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K(+) channel. Chapman, M.L., Blanke, M.L., Krovetz, H.S., Vandongen, A.M. Pflugers Arch. (2006) [Pubmed]
  7. KV2.1 K+ channels underlie major voltage-gated K+ outward current in H9c2 myoblasts. Wang, W., Hino, N., Yamasaki, H., Aoki, T., Ochi, R. Jpn. J. Physiol. (2002) [Pubmed]
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