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Gene Review

PTGIS  -  prostaglandin I2 (prostacyclin) synthase

Homo sapiens

Synonyms: CYP8, CYP8A1, PGIS, PTGI, Prostacyclin synthase, ...
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Disease relevance of PTGIS


High impact information on PTGIS


Chemical compound and disease context of PTGIS


Biological context of PTGIS


Anatomical context of PTGIS


Associations of PTGIS with chemical compounds

  • Bisulfite sequencing and clonal analysis confirmed the results obtained by AIMS and demonstrated biallelic hypermethylation of PTGIS promoter [1].
  • Homolytic fission of the O-O bond of peroxynitrite yields NO2. and HO.. The fact that 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), which reacts with NO. to form NO2., dramatically potentiated the IL-1beta effect suggests that NO2. could be a species implicated in the inactivation of PGIS [16].
  • The NO synthase inhibitor NG-monomethyl-L-arginine also antagonized the PGIS inhibitory effect of IL-1beta, indicating that NO. was also involved [16].
  • NO. reacts with O2-. to form peroxynitrite, which has been reported to inactivate PGIS [16].
  • The involvement of HO. in the PGIS inactivation was supported by the fact that deferoxamine, pyrrolidinedithiocarbamate, DMSO, mannitol, and captopril antagonized the effect of IL-1beta on PGIS to different degrees [16].

Regulatory relationships of PTGIS


Other interactions of PTGIS


Analytical, diagnostic and therapeutic context of PTGIS


  1. Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy. Frigola, J., Muñoz, M., Clark, S.J., Moreno, V., Capellà, G., Peinado, M.A. Oncogene (2005) [Pubmed]
  2. Assessment of the genetic component of hypertension. Yamada, Y., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Hibino, T., Yokoi, K., Ichihara, S., Metoki, N., Yoshida, H., Satoh, K., Nozawa, Y. Am. J. Hypertens. (2006) [Pubmed]
  3. Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. Keith, R.L., Miller, Y.E., Hoshikawa, Y., Moore, M.D., Gesell, T.L., Gao, B., Malkinson, A.M., Golpon, H.A., Nemenoff, R.A., Geraci, M.W. Cancer Res. (2002) [Pubmed]
  4. Immunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndrome. Govindarajan, S., Nast, C.C., Smith, W.L., Koyle, M.A., Daskalopoulos, G., Zipser, R.D. Hepatology (1987) [Pubmed]
  5. Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy. Végvári, A., Szabó, Z., Szántó, S., Nesterovitch, A.B., Mikecz, K., Glant, T.T., Adarichev, V.A. J. Immunol. (2005) [Pubmed]
  6. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. Du, X., Edelstein, D., Obici, S., Higham, N., Zou, M.H., Brownlee, M. J. Clin. Invest. (2006) [Pubmed]
  7. Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer. Shyue, S.K., Tsai, M.J., Liou, J.Y., Willerson, J.T., Wu, K.K. Circulation (2001) [Pubmed]
  8. Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. Keith, R.L., Miller, Y.E., Hudish, T.M., Girod, C.E., Sotto-Santiago, S., Franklin, W.A., Nemenoff, R.A., March, T.H., Nana-Sinkam, S.P., Geraci, M.W. Cancer Res. (2004) [Pubmed]
  9. Arthur C. Corcoran Memorial Lecture. The role of eicosanoids in angiotensin-dependent hypertension. Nasjletti, A. Hypertension (1998) [Pubmed]
  10. Posttransplant gastrointestinal perforation in pediatric liver transplantation. Yamanaka, J., Lynch, S.V., Ong, T.H., Balderson, G.A., Strong, R.W. J. Pediatr. Surg. (1994) [Pubmed]
  11. Cyclic mechanical stretch augments prostacyclin production in cultured human uterine myometrial cells from pregnant women: possible involvement of up-regulation of prostacyclin synthase expression. Korita, D., Sagawa, N., Itoh, H., Yura, S., Yoshida, M., Kakui, K., Takemura, M., Yokoyama, C., Tanabe, T., Fujii, S. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  12. Not prostacyclin synthase but prostaglandin endoperoxide synthase increases with human placental development. Keirse, M.J., Erwich, J.J., Klok, G. Prostaglandins (1986) [Pubmed]
  13. Human fallopian tubes express prostacyclin (PGI) synthase and cyclooxygenases and synthesize abundant PGI. Huang, J.C., Arbab, F., Tumbusch, K.J., Goldsby, J.S., Matijevic-Aleksic, N., Wu, K.K. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  14. Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium. Kawka, D.W., Ouellet, M., Hétu, P.O., Singer, I.I., Riendeau, D. Biochim. Biophys. Acta (2007) [Pubmed]
  15. Differential expression and regulation of cylooxygenases, prostaglandin E synthases and prostacyclin synthase in rat uterus during the peri-implantation period. Cong, J., Diao, H.L., Zhao, Y.C., Ni, H., Yan, Y.Q., Yang, Z.M. Reproduction (2006) [Pubmed]
  16. Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity. Camacho, M., López-Belmonte, J., Vila, L. Circ. Res. (1998) [Pubmed]
  17. Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines. Stearman, R.S., Grady, M.C., Nana-Sinkam, P., Varella-Garcia, M., Geraci, M.W. Mol. Cancer Res. (2007) [Pubmed]
  18. Prostacyclin-dependent apoptosis mediated by PPAR delta. Hatae, T., Wada, M., Yokoyama, C., Shimonishi, M., Tanabe, T. J. Biol. Chem. (2001) [Pubmed]
  19. Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in cultured endothelial cells. Liou, J.Y., Shyue, S.K., Tsai, M.J., Chung, C.L., Chu, K.Y., Wu, K.K. J. Biol. Chem. (2000) [Pubmed]
  20. Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy. Giannoulias, D., Alfaidy, N., Holloway, A.C., Gibb, W., Sun, M., Lye, S.J., Challis, J.R. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  21. Developmental regulation of prostacyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation period. Cammas, L., Reinaud, P., Bordas, N., Dubois, O., Germain, G., Charpigny, G. Reproduction (2006) [Pubmed]
  22. Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. Yokoyama, C., Yabuki, T., Inoue, H., Tone, Y., Hara, S., Hatae, T., Nagata, M., Takahashi, E.I., Tanabe, T. Genomics (1996) [Pubmed]
  23. Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. Poole, E.M., Bigler, J., Whitton, J., Sibert, J.G., Potter, J.D., Ulrich, C.M. Cancer Epidemiol. Biomarkers Prev. (2006) [Pubmed]
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