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Gene Review:

KCNS3 - potassium voltage-gated channel, modifier...

Homo sapiens

Synonyms: Delayed-rectifier K(+) channel alpha subunit 3, Kv9.3, Potassium voltage-gated channel subfamily S member 3, Voltage-gated potassium channel subunit Kv9.3

Wareing, M. et al., Hayama, E. et al., Patel, A.J. et al., Hao, K. et al., Patel, A.J. et al., et al.

Wareing, Bai, Seghier, Turner, Greenwood, Baker, Taggart, Fyfe, Yan, Figueroa, Austin, Liu, Bugianesi, Slaughter, Kaczorowski, Kohler,

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Disease relevance of KCNS3

In conclusion, we propose that metabolic regulation of the Kv2.1/Kv9.3 heteromultimer may play an important role in hypoxic PA vasoconstriction and in the possible development of PA hypertension [1].
Several voltage-gated K+ channel subunits comprising six transmembrane segments and a single pore domain (Kv1.2, Kv1.5, Kv2.1, Kv3.1, Kv3.3, Kv4.2 and Kv9.3) are reversibly blocked by hypoxia when expressed in heterologous expression systems [2].

High impact information on KCNS3

Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes [1].
Cell-specific markers were used to show that Kv2.1, Kv3.2, Kv6.2, and Kv9.3 are expressed in beta-cells, that Kv3.1 and Kv6.1 are expressed in alpha-cells, and that Kv2.2 is expressed in delta-cells [3].
Expression of Kvbeta1.3, Kvbeta1.4, Kv1.2, Kv2.1, and Kv9.3 was low in these blood vessels [4].
Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness [5].
We have evaluated a total of 12 single-nucleotide polymorphisms (SNPs) of the KCNS3 gene in a validation panel of 48 lymphoblastoid cell line DNA samples of Chinese origin [5].

Anatomical context of KCNS3

The present study determined the expression of Kvbeta1 and four oxygen-sensitive Kvalpha subunits (Kv1.2, Kv1.5, Kv2.1, and Kv9.3) in the ductus arteriosus (DA), the aorta (Ao), and the pulmonary artery (PA) in porcine neonates immediately after birth [4].

Associations of KCNS3 with chemical compounds

Remodeled DAMSCs are depolarized and express less O2-sensitive channels (including Kv2.1, Kv1.5, Kv9.3, Kv4.3, and BK(Ca)) [6].

Analytical, diagnostic and therapeutic context of KCNS3

The expression of voltage-gated (Kv)2.1, KV9.3, large-conductance Ca2+-activated K channel (BKCa), inward-rectified K+ channel (KIR)6.1, and two-pore domain inwardly rectifying potassium channel-related acid-sensitive K channels (TASK)1 in chorionic plate arteries, veins, and placental homogenate was assessed by RT-PCR and Western blot analysis [7].

References

Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. Patel, A.J., Lazdunski, M., Honoré, E. EMBO J. (1997) [Pubmed]
Molecular physiology of oxygen-sensitive potassium channels. Patel, A.J., Honoré, E. Eur. Respir. J. (2001) [Pubmed]
Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Yan, L., Figueroa, D.J., Austin, C.P., Liu, Y., Bugianesi, R.M., Slaughter, R.S., Kaczorowski, G.J., Kohler, M.G. Diabetes (2004) [Pubmed]
Analysis of voltage-gated potassium channel beta1 subunits in the porcine neonatal ductus arteriosus. Hayama, E., Imamura, S., Wu, C., Nakazawa, M., Matsuoka, R., Nakanishi, T. Pediatr. Res. (2006) [Pubmed]
Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness. Hao, K., Niu, T., Xu, X., Fang, Z., Xu, X. Hum. Genet. (2005) [Pubmed]
O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor. Michelakis, E.D., Rebeyka, I., Wu, X., Nsair, A., Thébaud, B., Hashimoto, K., Dyck, J.R., Haromy, A., Harry, G., Barr, A., Archer, S.L. Circ. Res. (2002) [Pubmed]
Expression and function of potassium channels in the human placental vasculature. Wareing, M., Bai, X., Seghier, F., Turner, C.M., Greenwood, S.L., Baker, P.N., Taggart, M.J., Fyfe, G.K. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]

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