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Gene Review

srtB  -  NPQTN specific sortase B

Staphylococcus aureus RF122

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Disease relevance of srtB


High impact information on srtB


Analytical, diagnostic and therapeutic context of srtB

  • Mean bacterial counts in cardiac vegetations were significantly higher for the wild-type and srtB- strain compared with the srtA- and srtA-B- strains [2].


  1. Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Bierne, H., Mazmanian, S.K., Trost, M., Pucciarelli, M.G., Liu, G., Dehoux, P., Jänsch, L., Garcia-del Portillo, F., Schneewind, O., Cossart, P. Mol. Microbiol. (2002) [Pubmed]
  2. Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection. Weiss, W.J., Lenoy, E., Murphy, T., Tardio, L., Burgio, P., Projan, S.J., Schneewind, O., Alksne, L. J. Antimicrob. Chemother. (2004) [Pubmed]
  3. The role of Staphylococcus aureus sortase A and sortase B in murine arthritis. Jonsson, I.M., Mazmanian, S.K., Schneewind, O., Bremell, T., Tarkowski, A. Microbes Infect. (2003) [Pubmed]
  4. An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Mazmanian, S.K., Ton-That, H., Su, K., Schneewind, O. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Differential recognition of surface proteins in Streptococcus pyogenes by two sortase gene homologs. Barnett, T.C., Scott, J.R. J. Bacteriol. (2002) [Pubmed]
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