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Gene Review

ileS  -  isoleucyl-tRNA synthetase

Staphylococcus aureus RF122

 
 
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Disease relevance of ileS

 

High impact information on ileS

 

Chemical compound and disease context of ileS

 

Biological context of ileS

 

Associations of ileS with chemical compounds

 

Analytical, diagnostic and therapeutic context of ileS

References

  1. Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870. Hodgson, J.E., Curnock, S.P., Dyke, K.G., Morris, R., Sylvester, D.R., Gross, M.S. Antimicrob. Agents Chemother. (1994) [Pubmed]
  2. Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics. Pope, A.J., Moore, K.J., McVey, M., Mensah, L., Benson, N., Osbourne, N., Broom, N., Brown, M.J., O'Hanlon, P. J. Biol. Chem. (1998) [Pubmed]
  3. Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. I: Kinetic mechanism of the substrate activation reaction studied by transient and steady-state techniques. Pope, A.J., Lapointe, J., Mensah, L., Benson, N., Brown, M.J., Moore, K.J. J. Biol. Chem. (1998) [Pubmed]
  4. Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques. Hurdle, J.G., O'Neill, A.J., Ingham, E., Fishwick, C., Chopra, I. Antimicrob. Agents Chemother. (2004) [Pubmed]
  5. The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden. Hurdle, J.G., O'Neill, A.J., Chopra, I. J. Antimicrob. Chemother. (2004) [Pubmed]
  6. Molecular Analysis of Isoleucyl-tRNA Synthetase Mutations in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus with Low-Level Mupirocin Resistance. Yang, J.A., Park, D.W., Sohn, J.W., Yang, I.S., Kim, K.H., Kim, M.J. J. Korean Med. Sci. (2006) [Pubmed]
  7. Identification of antimicrobial targets using a comprehensive genomic approach. Yin, D., Fox, B., Lonetto, M.L., Etherton, M.R., Payne, D.J., Holmes, D.J., Rosenberg, M., Ji, Y. Pharmacogenomics (2004) [Pubmed]
  8. Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A. Brown, M.J., Mensah, L.M., Doyle, M.L., Broom, N.J., Osbourne, N., Forrest, A.K., Richardson, C.M., O'Hanlon, P.J., Pope, A.J. Biochemistry (2000) [Pubmed]
  9. Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207. Crasto, C.F., Forrest, A.K., Karoli, T., March, D.R., Mensah, L., O'Hanlon, P.J., Nairn, M.R., Oldham, M.D., Yue, W., Banwell, M.G., Easton, C.J. Bioorg. Med. Chem. (2003) [Pubmed]
  10. Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A. Bennett, I., Broom, N.J., Cassels, R., Elder, J.S., Masson, N.D., O'Hanlon, P.J. Bioorg. Med. Chem. Lett. (1999) [Pubmed]
  11. The effect of antibiotic treatment on the intracellular nucleotide pools of Staphylococcus aureus. Greenwood, R.C., Gentry, D.R. FEMS Microbiol. Lett. (2002) [Pubmed]
  12. The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the alpha,beta-unsaturated ester: synthesis, molecular modeling, and antibacterial activity. Brown, P., Best, D.J., Broom, N.J., Cassels, R., O'Hanlon, P.J., Mitchell, T.J., Osborne, N.F., Wilson, J.M. J. Med. Chem. (1997) [Pubmed]
  13. Use of the polymerase chain reaction for rapid detection of high-level mupirocin resistance in staphylococci. Anthony, R.M., Connor, A.M., Power, E.G., French, G.L. Eur. J. Clin. Microbiol. Infect. Dis. (1999) [Pubmed]
 
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