Gene Review:
ileS - isoleucyl-tRNA synthetase
Staphylococcus aureus RF122
- Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870. Hodgson, J.E., Curnock, S.P., Dyke, K.G., Morris, R., Sylvester, D.R., Gross, M.S. Antimicrob. Agents Chemother. (1994)
- Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics. Pope, A.J., Moore, K.J., McVey, M., Mensah, L., Benson, N., Osbourne, N., Broom, N., Brown, M.J., O'Hanlon, P. J. Biol. Chem. (1998)
- Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. I: Kinetic mechanism of the substrate activation reaction studied by transient and steady-state techniques. Pope, A.J., Lapointe, J., Mensah, L., Benson, N., Brown, M.J., Moore, K.J. J. Biol. Chem. (1998)
- Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques. Hurdle, J.G., O'Neill, A.J., Ingham, E., Fishwick, C., Chopra, I. Antimicrob. Agents Chemother. (2004)
- The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden. Hurdle, J.G., O'Neill, A.J., Chopra, I. J. Antimicrob. Chemother. (2004)
- Molecular Analysis of Isoleucyl-tRNA Synthetase Mutations in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus with Low-Level Mupirocin Resistance. Yang, J.A., Park, D.W., Sohn, J.W., Yang, I.S., Kim, K.H., Kim, M.J. J. Korean Med. Sci. (2006)
- Identification of antimicrobial targets using a comprehensive genomic approach. Yin, D., Fox, B., Lonetto, M.L., Etherton, M.R., Payne, D.J., Holmes, D.J., Rosenberg, M., Ji, Y. Pharmacogenomics (2004)
- Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A. Brown, M.J., Mensah, L.M., Doyle, M.L., Broom, N.J., Osbourne, N., Forrest, A.K., Richardson, C.M., O'Hanlon, P.J., Pope, A.J. Biochemistry (2000)
- Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207. Crasto, C.F., Forrest, A.K., Karoli, T., March, D.R., Mensah, L., O'Hanlon, P.J., Nairn, M.R., Oldham, M.D., Yue, W., Banwell, M.G., Easton, C.J. Bioorg. Med. Chem. (2003)
- Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A. Bennett, I., Broom, N.J., Cassels, R., Elder, J.S., Masson, N.D., O'Hanlon, P.J. Bioorg. Med. Chem. Lett. (1999)
- The effect of antibiotic treatment on the intracellular nucleotide pools of Staphylococcus aureus. Greenwood, R.C., Gentry, D.R. FEMS Microbiol. Lett. (2002)
- The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the alpha,beta-unsaturated ester: synthesis, molecular modeling, and antibacterial activity. Brown, P., Best, D.J., Broom, N.J., Cassels, R., O'Hanlon, P.J., Mitchell, T.J., Osborne, N.F., Wilson, J.M. J. Med. Chem. (1997)
- Use of the polymerase chain reaction for rapid detection of high-level mupirocin resistance in staphylococci. Anthony, R.M., Connor, A.M., Power, E.G., French, G.L. Eur. J. Clin. Microbiol. Infect. Dis. (1999)