The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Cr1  -  Ig kappa chain

Mus musculus

This record was replaced with 16098.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cr1

  • A total of 113 primary murine hematopoietic neoplasms, including those of erythroid, granulocytic, and T and B lymphoid lineages, were examined for rearrangement of immunoglobulin heavy (IgH) and kappa light chain (IgK) and T cell receptor beta and gamma (TcR-beta and TcR-gamma) genes [1].

High impact information on Cr1


Biological context of Cr1


Anatomical context of Cr1


Analytical, diagnostic and therapeutic context of Cr1

  • The SP1.4 heavy and kappa light chain variable region genes, spliced by overlap PCR to a mammalian signal peptide, were transferred to expression vectors for human IgG1, IgG4, and kappa L chains [12].


  1. Early divergence of erythroid lineage suggested by gene rearrangements in mouse hematopoietic neoplasms. Fredrickson, T.N., Hartley, J.W., Morse, H.C. Exp. Hematol. (1993) [Pubmed]
  2. Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms. Reininger, L., Berney, T., Shibata, T., Spertini, F., Merino, R., Izui, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Pax-5 is essential for kappa sterile transcription during Ig kappa chain gene rearrangement. Sato, H., Saito-Ohara, F., Inazawa, J., Kudo, A. J. Immunol. (2004) [Pubmed]
  4. A shared kappa reciprocal fragment and a high frequency of secondary Jk5 rearrangements among influenza hemagglutinin specific B cell hybridomas. Clarke, S., McCray, S. J. Immunol. (1991) [Pubmed]
  5. T cell responses to cleaved rabies virus glycoprotein and to synthetic peptides. Macfarlan, R.I., Dietzschold, B., Wiktor, T.J., Kiel, M., Houghten, R., Lerner, R.A., Sutcliffe, J.G., Koprowski, H. J. Immunol. (1984) [Pubmed]
  6. Monoclonal antibodies to streptococcal group A carbohydrate. II. The VK1GAC light chain is preferentially associated with serum IgG3. Fulton, R.J., Nahm, M.H., Davie, J.M. J. Immunol. (1983) [Pubmed]
  7. Analysis of the structural integrity of YACs comprising human immunoglobulin genes in yeast and in embryonic stem cells. Mendez, M.J., Abderrahim, H., Noguchi, M., David, N.E., Hardy, M.C., Green, L.L., Tsuda, H., Yoast, S., Maynard-Currie, C.E., Garza, D. Genomics (1995) [Pubmed]
  8. Nucleotide sequence of a new BALB/c mouse kappa light chain variable region gene. Xu, D., Tsang, K.Y. Nucleic Acids Res. (1990) [Pubmed]
  9. Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice. Kumar, M., Hunag, Y., Glinka, Y., Prud'homme, G.J., Wang, Q. Gene Ther. (2007) [Pubmed]
  10. Characterization of a V kappa family in Mus musculus castaneus: sequence analysis. Henderson, T.J., Rudikoff, S. Immunogenetics (1993) [Pubmed]
  11. Molecular cloning, expression, and characterization of a functional single-chain Fv antibody to the mycotoxin zearalenone. Yuan, Q., Clarke, J.R., Zhou, H.R., Linz, J.E., Pestka, J.J., Hart, L.P. Appl. Environ. Microbiol. (1997) [Pubmed]
  12. Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: evidence for thyroid cell damage by IgG1, but not IgG4, autoantibodies. Guo, J., Jaume, J.C., Rapoport, B., McLachlan, S.M. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
WikiGenes - Universities