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Gene Review

INSC  -  inscuteable homolog (Drosophila)

Homo sapiens

Synonyms: Protein inscuteable homolog
 
 
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Disease relevance of INSC

 

High impact information on INSC

  • Here we describe cloning of two distinct cDNAs from human Insc gene, which is differentially expressed from alternative first exons: one encodes 579 amino acids, whereas the other lacks the N-terminal 47 amino acids [2].
  • The phospholipase C inhibitor, U-73122 inhibited INSC and the sustained Ca2+ plateau during agonist stimulation whereas the inactive analogue, U-73343 had no effect [3].
  • (v) Application of 2,5-di-tert-butylhydroquinone and internal perfusion of inositol 1,4,5-trisphosphate also activated INSC [3].
  • (ii) Stimulation with ATP, histamine and bradykinin activated slowly and with a long delay after application of the agonist, a nonselective cation current (INSC) which is time- and voltage-independent [3].
  • Here, we identified and characterized human Inscuteable (INSC) gene using bioinformatics [1].
 

Biological context of INSC

  • The Italian National Inventory of Chemical Substances (Inventario nazionale delle sostanze chimiche, INSC), a factual data bank on chemical toxicology produced by the Istituto Superiore di Sanità (ISS), consists of a computerized system on existing chemicals developed for routinary and emergency needs [4].
  • Human INSC gene, consisting of at least 13 exons, was located within human genome draft sequence AC090744.5 (around nucleotide position 150581-16936 in reverse orientation) [1].
  • 1. Amino-acid sequence of human INSC polypeptide (579 aa) was determined based on exon sequences of human INSC gene [1].
  • Human INSC gene, closely linked to CALCB gene with an interval of about 30 kb, was assigned to human chromosome 11p15.2-p15 [1].

References

  1. Identification and characterization of human Inscuteable gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
  2. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. Izaki, T., Kamakura, S., Kohjima, M., Sumimoto, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. Nonselective cation channels in endothelial cells derived from human umbilical vein. Kamouchi, M., Mamin, A., Droogmans, G., Nilius, B. J. Membr. Biol. (1999) [Pubmed]
  4. Features of the Italian National Inventory of Chemical Substances. Binetti, R., Marcello, I. Ann. Ist. Super. Sanita (1994) [Pubmed]
 
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