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Chemical Compound Review

tBuBHQ     2,5-ditert-butylbenzene-1,4- diol

Synonyms: DTBHQ, Dibug, Dybug, DBHQ, t-BuBHQ, ...
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Disease relevance of Santovar O


High impact information on Santovar O


Chemical compound and disease context of Santovar O


Biological context of Santovar O


Anatomical context of Santovar O


Associations of Santovar O with other chemical compounds


Gene context of Santovar O

  • The magnitude of dilatation was markedly reduced by removing Ca2+ from the intraluminal flow medium.Depletion of intracellular Ca2+ stores with either cyclopiazonic acid (CPA, 2 microM) or 1,4-dihydroxy-2,5-di-tert-butylbenzene (BHQ, 10 microM) significantly augmented the magnitude of flow dilatation [18].
  • When K+ channels were blocked, SP activated a net inward current with a reversal potential (2.5 +/- 1 mV) not significantly different from that (2 +/- 1 mV) for inward current recorded in response to store depletion by (2,5-di-tert-butylhydroquinone) (BHQ, 10 microM) [19].

Analytical, diagnostic and therapeutic context of Santovar O


  1. Evidence from studies with hepatocyte suspensions that store-operated Ca2+ inflow requires a pertussis toxin-sensitive trimeric G-protein. Fernando, K.C., Barritt, G.J. Biochem. J. (1994) [Pubmed]
  2. Phosphatidylserine synthesis in glioma C6 cells is inhibited by Ca2+ depletion from the endoplasmic reticulum: effects of 2,5-di-tert-butylhydroquinone and thimerosal. Wiktorek, M., Sabała, P., Czarny, M., Barańska, J. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  3. Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration. Zhang, B.H., Hornsfield, B.P., Farrell, G.C. J. Clin. Invest. (1996) [Pubmed]
  4. Agonist-evoked mitochondrial Ca2+ signals in mouse pancreatic acinar cells. González, A., Schulz, I., Schmid, A. J. Biol. Chem. (2000) [Pubmed]
  5. Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells. Charlesworth, A., Rozengurt, E. J. Biol. Chem. (1994) [Pubmed]
  6. Origin of slow and fast oscillations of Ca2+ in mouse pancreatic islets. Liu, Y.J., Tengholm, A., Grapengiesser, E., Hellman, B., Gylfe, E. J. Physiol. (Lond.) (1998) [Pubmed]
  7. Intracellular pH and calcium in frog early distal tubule: effects of transport inhibitors. Cooper, G.J., Hunter, M. J. Physiol. (Lond.) (1997) [Pubmed]
  8. Prostaglandin F2alpha-induced Ca++ oscillations in human myometrial cells and the role of RU 486. Fu, X., Favini, R., Kindahl, K., Ulmsten, U. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  9. Pinocytosis in 2,5-di-tert-butylhydroquinone-stimulated hepatocytes and evaluation of its role in Ca2+ inflow. Fernando, K.C., Barritt, G.J. Mol. Cell. Biochem. (1996) [Pubmed]
  10. Contribution of oxygen radicals to DNA cleavage by quinone compounds derived from phenolic antioxidants, tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone. Okubo, T., Nagai, F., Ushiyama, K., Kano, I. Toxicol. Lett. (1997) [Pubmed]
  11. Suppression of EGF-induced cell proliferation by the blockade of Ca2+ mobilization and capacitative Ca2+ entry in mouse mammary epithelial cells. Ichikawa, J., Kiyohara, T. Cell Biochem. Funct. (2001) [Pubmed]
  12. Depletion of the inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ store in vascular endothelial cells activates the agonist-sensitive Ca(2+)-influx pathway. Schilling, W.P., Cabello, O.A., Rajan, L. Biochem. J. (1992) [Pubmed]
  13. Effects of 2,5-di-tert-butylhydroquinone on rat cardiac muscle contractility. Kabbara, A.A., Stephenson, D.G. Am. J. Physiol. (1997) [Pubmed]
  14. Calcium handling by sarcoplasmic reticulum of neonatal swine cardiac myocytes. Hohl, C.M., Livingston, B., Hensley, J., Altschuld, R.A. Am. J. Physiol. (1997) [Pubmed]
  15. Osmotic swelling-induced changes in cytosolic calcium do not affect regulatory volume decrease in rat cultured suspended cerebellar astrocytes. Morales-Mulia, S., Vaca, L., Hernandez-Cruz, A., Pasantes-Morales, H. J. Neurochem. (1998) [Pubmed]
  16. Nonselective cation channels in endothelial cells derived from human umbilical vein. Kamouchi, M., Mamin, A., Droogmans, G., Nilius, B. J. Membr. Biol. (1999) [Pubmed]
  17. Effect of intracellular pH on acetylcholine-induced Ca2+ waves in mouse pancreatic acinar cells. González, A., Pfeiffer, F., Schmid, A., Schulz, I. Am. J. Physiol. (1998) [Pubmed]
  18. Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery. Liu, C., Ngai, C.Y., Huang, Y., Ko, W.H., Wu, M., He, G.W., Garland, C.J., Dora, K.A., Yao, X. Br. J. Pharmacol. (2006) [Pubmed]
  19. Substance P-induced calcium entry in endothelial cells is secondary to depletion of intracellular stores. Sharma, N.R., Davis, M.J. Am. J. Physiol. (1995) [Pubmed]
  20. Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells. Jan, C.R., Ho, C.M., Wu, S.N., Tseng, C.J. Eur. J. Pharmacol. (1999) [Pubmed]
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